Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation

Autor: Ronald Jacobi, Sanne Spijkers, Dan Koning, Rob Schuurman, Leonie Ran, Ingrid M. M. Schellens, Ellen Meijer, Henny G. Otten, Suzanne van Dorp, Julia Drylewicz, Esther D. Quakkelaar, Floortje L Pietersma, Jürgen Kuball, Rogier Gaiser, Debbie van Baarle, Nening M. Nanlohy
Přispěvatelé: Hematology, AII - Inflammatory diseases
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
CD4-Positive T-Lymphocytes
Male
Cytomegalovirus
CD8-Positive T-Lymphocytes
0302 clinical medicine
Risk Factors
immune system diseases
hemic and lymphatic diseases
Medicine
Longitudinal Studies
Medicine(all)
biology
Stem cell transplantation
CMV
Receptors
KIR3DL1
General Medicine
Middle Aged
Prognosis
3. Good health
Killer Cells
Natural
surgical procedures
operative
medicine.anatomical_structure
Female
Stem cell
Viral load
Adult
Adolescent
T cell
General Biochemistry
Genetics and Molecular Biology
CD19
Virus
03 medical and health sciences
Young Adult
Immune system
EBV
Journal Article
Humans
Transplantation
Homologous
Aged
Proportional Hazards Models
Biochemistry
Genetics and Molecular Biology(all)
business.industry
Research
Immune reconstitution
Virology
Transplantation
030104 developmental biology
Cytoprotection
Immunology
biology.protein
business
CD8
030215 immunology
Zdroj: Journal of Translational Medicine
Journal of Translational Medicine [E], 14(1). BioMed Central
Drylewicz, J, Schellens, I M M, Gaiser, R, Nanlohy, N M, Quakkelaar, E D, Otten, H, van Dorp, S, Jacobi, R, Ran, L, Spijkers, S, Koning, D, Schuurman, R, Meijer, E, Pietersma, F L, Kuball, J & van Baarle, D 2016, ' Rapid reconstitution of CD4 T cells and NK cells protects against CMV-reactivation after allogeneic stem cell transplantation ', Journal of Translational Medicine, vol. 14, no. 1, pp. 230 . https://doi.org/10.1186/s12967-016-0988-4
Journal of Translational Medicine, 14(1). BioMed Central
ISSN: 1479-5876
DOI: 10.1186/s12967-016-0988-4
Popis: Background Epstein-Barr virus and Cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (SCT). Methods Here we investigated the role of immune cell reconstitution in the onset and subsequent severity of EBV- and CMV-reactivation. To this end, 116 patients were prospectively sampled for absolute T cell (CD4 and CD8), B-cell (CD19) and NK-cell (CD16 and CD56) numbers weekly post-SCT during the first 3 months and thereafter monthly until 6 months post-SCT. Viral load was monitored in parallel. Results In contrast to the general belief, we found that early T-cell reconstitution does not play a role in the onset of viral reactivation. CMV reactivation in the first 7 weeks after SCT however resulted in higher absolute CD8+ T-cell numbers 6 months post-SCT in patients with high-level reactivation, many of which were CMV-specific. Interestingly, rapid reconstitution of CD4+ T-cells, as well as NK cells and the presence of donor KIR3DL1, are associated with the absence of CMV-reactivation after SCT, suggestive of a protective role of these cells. In contrast, EBV-reactivations were not affected in any way by the level of immune reconstitution after SCT. Conclusion In conclusion, these data suggest that CD4+ T-cells and NK cells, rather than CD8+ T-cells, are associated with protection against CMV-reactivation. Electronic supplementary material The online version of this article (doi:10.1186/s12967-016-0988-4) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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