Anti-endothelial antibodies and coronary artery disease after cardiac transplantation
| Autor: | Patricia M. Taylor, Michael J. Dunn, Crisp Sj, Magdi H. Yacoub, Marlene L. Rose |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Endothelium Adolescent medicine.medical_treatment Blotting Western Fluorescent Antibody Technique Coronary Disease Disease Immunofluorescence Umbilical vein Antibodies Coronary artery disease Postoperative Complications Internal medicine medicine Humans Cells Cultured Aged Heart transplantation medicine.diagnostic_test biology business.industry General Medicine Middle Aged medicine.disease Transplantation medicine.anatomical_structure Immunoglobulin M biology.protein Cardiology Heart Transplantation Female Endothelium Vascular Antibody business |
| Zdroj: | Lancet (London, England). 339(8809) |
| ISSN: | 0140-6736 |
| Popis: | Accelerated coronary artery disease is the most serious complication after cardiac transplantation. The disease has a multifactorial aetiology, with little agreement about the relative importance of the various risk factors. We have investigated the frequency of anti-endothelial antibodies against human umbilical vein endothelial cells by one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis and western blotting. Peptide-specific anti-endothelial antibodies were found in 15/21 heart transplant recipients with accelerated coronary artery disease, and 1/20 transplant patients who had not developed the disease. Positive immunofluorescence of patients' serum on frozen sections of coronary vessels confirmed the endothelial specificity of antibodies. These results provide evidence of an immune aetiology for transplant-associated coronary artery disease and could have important implications for its diagnosis and therapy. |
| Databáze: | OpenAIRE |
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