Epstein-Barr virus involvement is a predictive factor for the resistance to chemoradiotherapy of gastric diffuse large B-cell lymphoma
| Autor: | Atsushi Ochiai, Atsushi Ohtsu, Yukio Kobayashi, Ichiro Oda, Kensei Tobinai, Tadashi Yoshino, Satoshi Ishikura, Yoshihiro Matsuno, Shigeo Nakamura, Junji Suzumiya, Kiyomi Mera, Yasuhiko Kitadai, Takio Yokoi |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Epstein-Barr Virus Infections Herpesvirus 4 Human Cancer Research Vincristine Pathology medicine.medical_specialty Lymphoma B-Cell Combination therapy Radiation Tolerance Gastroenterology Stomach Neoplasms Prednisone hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Medicine Cerebellar Neoplasms Cyclophosphamide In Situ Hybridization Neoplasm Staging business.industry Remission Induction Combination chemotherapy General Medicine Middle Aged Gastric Diffuse Large B-Cell Lymphoma Prognosis medicine.disease Lymphoma Survival Rate Oncology Doxorubicin Drug Resistance Neoplasm Disease Progression RNA Viral Female Lymphoma Large B-Cell Diffuse Neoplasm Recurrence Local business Progressive disease Chemoradiotherapy medicine.drug |
| Zdroj: | Cancer Science. 97:163-166 |
| ISSN: | 1349-7006 1347-9032 |
| DOI: | 10.1111/j.1349-7006.2006.00155.x |
| Popis: | Primary gastric diffuse large B-cell lymphomas are generally well controlled by non-surgical treatment with combination chemotherapy followed by radiotherapy. We have previously reported that over 90% of patients achieved complete response (CR) with this therapeutic strategy: three cycles of cyclophosphamide, adriamycin, vincristine and prednisone followed by radiotherapy (40.5 Gy). Although the CR rate was very high, some patients still showed resistance to this combination therapy. In order to clarify the factors related to therapy resistance, we examined the relationship between Epstein-Barr virus (EBV), which was examined using an in situ hybridization technique, and the patients' clinical courses. Out of the 50 patients, four were EBV positive; over half of lymphoma cells were positive for EBV by in situ hybridization. Of the three EBV-positive patients, two showed progressive disease and one achieved partial response (PR). Two of the patients died of disease progression. The other patient achieved CR, but the lymphoma recurred with distant metastasis in the cerebellum 3 months after remission. In the present study, eight patients did not achieve CR or they relapsed, four patients showed progressive disease, one patient achieved PR, and three patients achieved CR with recurrence. Therefore, half of these unfavorable patients were EBV positive. This finding strongly indicated that EBV-associated gastric diffuse large B-cell lymphomas frequently show resistance to standard chemoradiotherapy, although some other adverse factors remain unclear. |
| Databáze: | OpenAIRE |
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