Creation of nano eye-drops and effective drug delivery to the interior of the eye
Autor: | Kota Sato, Yuji Tanaka, Hitoshi Kasai, Yoshikazu Ikuta, Hidetoshi Oikawa, Tsunenobu Onodera, Satoshi Inada, Shigenobu Aoyagi, Yoshitaka Koseki |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Materials science genetic structures Brinzolamide Thiazines Glaucoma 02 engineering and technology 010402 general chemistry 01 natural sciences Article Rats Sprague-Dawley Drug Delivery Systems Cornea Nano medicine Animals Prodrugs Corneal epithelium Sulfonamides Multidisciplinary technology industry and agriculture Epithelium Corneal Prodrug 021001 nanoscience & nanotechnology medicine.disease eye diseases 0104 chemical sciences Rats medicine.anatomical_structure Drug delivery Nanoparticles sense organs Penetration rate Ophthalmic Solutions 0210 nano-technology Biomedical engineering medicine.drug |
Zdroj: | Scientific Reports |
ISSN: | 2045-2322 |
DOI: | 10.1038/srep44229 |
Popis: | Nano eye-drops are a new type of ophthalmic treatment with increased potency and reduced side effects. Compounds in conventional eye-drops barely penetrate into the eye because the cornea, located at the surface of eye, has a strong barrier function for preventing invasion of hydrophilic or large-sized materials from the outside. In this work, we describe the utility of nano eye-drops utilising brinzolamide, a commercially available glaucoma treatment drug, as a target compound. Fabrication of the nanoparticles of brinzolamide prodrug increases the eye penetration rate and results in high drug efficacy, compared with that of commercially available brinzolamide eye-drops formulated as micro-sized structures. In addition, the resulting nano eye-drops were not toxic to the corneal epithelium after repeated administration for 1 week. The nano eye-drops may have applications as a next-generation ophthalmic treatment. |
Databáze: | OpenAIRE |
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