Effect of atenolol on symptomatic ventricular arrhythmia without structural heart disease: A randomized placebo-controlled study
| Autor: | Rungroj Krittayaphong, Kesaree Punlee, Kiertijai Bhuripanyo, Charuwan Kangkagate, Suphachai Chaithiraphan |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Heart Ventricles Adrenergic beta-Antagonists Placebo-controlled study Ventricular tachycardia Placebo Double-Blind Method Internal medicine Heart rate medicine Humans Ventricular outflow tract cardiovascular diseases business.industry Arrhythmias Cardiac Blood Pressure Monitoring Ambulatory Placebo Effect medicine.disease Atenolol Anesthesia Ambulatory Quality of Life Cardiology Female Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents medicine.drug |
| Zdroj: | American Heart Journal. 144:1-5 |
| ISSN: | 0002-8703 |
| DOI: | 10.1067/mhj.2002.125516 |
| Popis: | Background Ventricular arrhythmia (VA) from the right ventricular outflow tract (RVOT) is a common problem. Symptomatic patients are usually treated with β-blockers. There is little data on the systematic evaluation of the efficacy of β-blocker. We determine the efficacy of atenolol in the treatment of symtomatic VA from RVOT compared with placebo. Methods and Results This was a randomized, double-blinded, placebo-controlled study. We prospectively studied 52 consecutive patients with symptomatic VA. Severity of symptoms, 24-hour ambulatory monitoring (AECG) and quality of life (QOL) were assessed at baseline and 1 month after atenolol. Exercise testing was performed at baseline. Average premature ventricular complex (PVC) count at baseline was 21,407 ± 1740 beats per 24 hours, and 19% had ventricular tachycardia as measured by AECG. Results of this study showed that atenolol significantly decreased symptom frequency ( P =.03), PVC count ( P =.001) and average heart rate ( P P =.002) but had no effect on PVC count ( P =.78) or average heart rate ( P =.44). Neither atenolol nor placebo had an effect on QOL. Conclusions Atenolol improves symptoms and decreases PVC count from ambulatory monitoring. Placebo improved symptoms to the same extent as atenolol but had no effect on severity of VA. This might be the so-called placebo effect, which is a concern when treating patients or doing research on the effects of a drug. (Am Heart J 2002;144:e15.) |
| Databáze: | OpenAIRE |
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