Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
| Autor: | Nirupama Shivakumar, Farook Jahoor, Sarita Devi, Arpita Mukhopadhyay, Ambily Sivadas, John McLaughlin, Craig P. Smith, Anura V Kurpad |
|---|---|
| Přispěvatelé: | Zoetendal, Erwin G. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Bifidobacterium longum ved/biology.organism_classification_rank.species Physiology Gut flora Linear Discriminant Analysis Biochemistry Families Mathematical and Statistical Techniques Child Development fluids and secretions Medicine and Health Sciences Wasting Children Bifidobacterium Sex Characteristics Multidisciplinary Bifidobacterium breve biology Statistics food and beverages Genomics Medical Microbiology Child Preschool Physical Sciences Medicine Female medicine.symptom Anatomy Research Article Science 030106 microbiology Microbial Genomics Research and Analysis Methods Biosynthesis Microbiology digestive system 03 medical and health sciences medicine Genetics Humans Microbiome Statistical Methods Nutrition Bifidobacterium bifidum Intestinal permeability Bacteria ved/biology Gut Bacteria Organisms Biology and Life Sciences Infant biology.organism_classification medicine.disease Gastrointestinal Microbiome Gastrointestinal Tract 030104 developmental biology Age Groups People and Places Population Groupings Digestive System Mathematics |
| Zdroj: | PLoS ONE, Vol 16, Iss 5, p e0251803 (2021) PLoS ONE Shivakumar, N, Sivadas, A, Devi, S, Jahoor, F, Mclaughlin, J, Smith, C P, Kurpad, A V, Mukhopadhyay, A & Zoetendal, E G (ed.) 2021, ' Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth ', PLoS ONE, vol. 16, no. 5, e0251803 . https://doi.org/10.1371/journal.pone.0251803 |
| ISSN: | 1932-6203 |
| Popis: | Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18–24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth. |
| Databáze: | OpenAIRE |
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