Increased salivary fluid flow in children with newly diagnosed allergic rhinitis
Autor: | Cai-Xia Qiu, Si Ai, Xiangli Zhuang, Jian Zheng, Suping Huang |
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Rok vydání: | 2018 |
Předmět: |
Male
medicine.medical_specialty Saliva Sympathetic nervous system Immunoblotting Gene Dosage Newly diagnosed Autonomic Nervous System Real-Time Polymerase Chain Reaction Pathogenesis 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Internal medicine medicine Humans Secretion 030223 otorhinolaryngology Child Morning business.industry General Medicine Salivary flow rate Rhinitis Allergic DNA-Binding Proteins Autonomic nervous system Endocrinology medicine.anatomical_structure Otorhinolaryngology Salivary alpha-Amylases Pediatrics Perinatology and Child Health Female business Transcription Factors |
Zdroj: | International journal of pediatric otorhinolaryngology. 117 |
ISSN: | 1872-8464 |
Popis: | Objectives The pathogenesis of allergic rhinitis (AR) may involve dysregulation of the autonomic nervous system (ANS). Salivary fluid flow and salivary alpha-amylase (sAA) secretion are able to reflect the activity of parasympathetic (PNS) and sympathetic nervous system (SNS), respectively. The study aims to address the ANS profile in children with newly diagnosed AR by measuring the salivary secretion pattern. Methods We recruited thirty-three children with newly diagnosed AR and thirty-one age- and sex-matched healthy children as control. Saliva samples were collected in the morning and the salivary parameters, including salivary flow rate (SFR, ml/min) and sAA secretion rate (μg/min), were determined accordingly. We also measured the gene copy number of the sAA gene, AMY1, for each individual. Results We detected a significantly higher SFR in AR children compared with healthy control (2.20 ± 0.55 vs. 1.63 ± 0.61; p = 0.0002). Similar sAA secretion rate was observed between the two groups (312.8 ± 124.8 (Healthy) vs. 347.9 ± 114.0 (AR) μg/min; p = 0.2444). Besides, the two groups did not differ in AMY1 gene copy number (7.2 ± 2.3 (Healthy) vs. 7.7 ± 2.2 (AR); p = 0.3493). Conclusions Our results implicate an overactivity of the PNS while normal SNS activity in children with newly diagnosed AR. The findings support a contributing role of the ANS dysfunction in the pathogenesis of AR. |
Databáze: | OpenAIRE |
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