Risk factors for mortality of adult patients with COVID-19 hospitalised in an emerging country: a cohort study
| Autor: | Enrique Rojas-Campos, Hugo R Hernandez-García, José Juan Ramírez-Márquez, Carlos Acosta-Ramírez, Mario A. Mireles-Ramírez, María Claudia Espinel-Bermúdez, Maribel Ávila-Morán, Ramón I De-Dios-Pérez, Sandra O. Hernández-González, Porfirio Eduardo Martínez-Gutiérrez, Clotilde Fuentes-Orozco, Arnulfo Hernán Nava-Zavala, Laura Cortés-Sanabria, Luz Ma Adriana Balderas-Peña, Alfonso M. Cueto-Manzano, Alejandro González-Ojeda |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Disease 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Medicine Humans 030212 general & internal medicine Hospital Mortality Prospective Studies Prospective cohort study Mexico Aged Mechanical ventilation business.industry SARS-CoV-2 Public health public health COVID-19 General Medicine medicine.disease Triage Respiration Artificial internal medicine Intensive Care Units Infectious Diseases business Kidney disease Cohort study |
| Zdroj: | BMJ Open, Vol 11, Iss 7 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveTo describe mortality of in-hospital patients with COVID-19 and compare risk factors between survivors and non-survivors.DesignProspective cohort of adult inpatients.SettingTertiary healthcare teaching hospital in Guadalajara, Mexico.ParticipantsAll patients with confirmed COVID-19 hospitalised from 25 March to 7 September 2020 were included. End of study: 7 November 2020.Primary outcome measuresPatient survival analysed by the Kaplan-Meier method and comparison of factors by the log-rank test. Mortality risk factors analysed by multivariate Cox’s proportional-hazard model.ResultsOne thousand ten patients included: 386 (38%) died, 618 (61%) alive at discharge and six (0.6%) remained hospitalised. There was predominance of men (63%) and high frequency of overweight–obesity (71%); hypertension (54%); diabetes (40%); and lung (9%), cardiovascular (8%) and kidney diseases (11%); all of them significantly more frequent in non-survivors. Overweight–obesity was not different between groups, but severity of disease (Manchester Triage System and quick Sequential Organ Failure Assessment) was significantly worse in non-survivors, who were also significantly older (65 vs 45 years, respectively) and had haematological, biochemical, coagulation and inflammatory biomarkers more altered than survivors. Mortality predictors were invasive mechanical ventilation (IMV; OR 3.31, pConclusionsMortality in hospitalised patients with COVID-19 in this emerging country centre seemed to be higher than in developed countries. Patients displayed a high frequency of risk factors for poor outcome, but the need for IMV, ICU admission, older age, more severe disease at admission, antecedent of kidney disease and higher CRP levels significantly predicted mortality. |
| Databáze: | OpenAIRE |
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