Test-guided dietary management of eczema in children: A randomized controlled feasibility trial (TEST)
| Autor: | Kirsty Roberts, Douglas Webb, Joanna Coast, Ingrid Muller, Lucy E Selman, Matthew J Ridd, Joe Kai, Joanne R Chalmers, Jodi Taylor, Deb Marriage, Miriam Santer, Elizabeth Angier, Alison Shaw, Lisa Waddell, Anna Gilbertson, Nicholas Turner, Peter S Blair, Clare Clement, Kirsty Garfield, Robert J. Boyle |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Parents Allergy medicine.medical_specialty Attitude of Health Personnel Immunology Primary care Dermatitis Atopic 03 medical and health sciences 0302 clinical medicine Food allergy atopic eczema dermatitis feasibility RCT food allergy paediatrics medicine HEB Immunology and Allergy Humans Adverse effect Qualitative Research Skin Tests business.industry Oral food challenge Dietary management Infant medicine.disease Clinical trial 030104 developmental biology 030228 respiratory system Family medicine Child Preschool Usual care Feasibility Studies Female business Attitude to Health Food Hypersensitivity |
| Zdroj: | Ridd, M J, Webb, D P S, Roberts, K A, Santer, M, Chalmers, J R, Gilbertson, A L, Marriage, D, Blair, P S, Turner, N L, Garfield, K M, Coast, J, Selman, L E, Clement, C, Shaw, A R G, Muller, I, Waddell, L, Angier, E, Taylor, J, Boyle, R J & Kai, J 2021, ' Test-guided dietary management of eczema in children : A randomized controlled feasibility trial (TEST) ', Clinical and Experimental Allergy, vol. 51, no. 3, pp. 452-462 . https://doi.org/10.1111/cea.13816 |
| ISSN: | 1365-2222 0954-7894 |
| DOI: | 10.1111/cea.13816 |
| Popis: | Background: parents commonly ask about food allergy tests, to find a cause for their child's eczema, yet the value of routine testing is uncertain. Objective: To determine whether a clinical trial comparing test-guided dietary advice versus usual care, for the management of eczema, is feasible. Methods: children (>3 months and Results: from 1059 invitation letters sent to carers of potentially eligible children, 84 were randomized (42 per group) with mean age of 32.4 months (SD 13.9) and POEM of 8.7 (4.8). Of the 42, 6 (14%) intervention participants were advised to exclude one or more foods, most commonly egg, peanut or milk. By participant, 1/6 had an oral food challenge (negative); 3/6 were told to exclude until review in allergy clinic; and 6/6 advised a home dietary trial (exclusion and reintroduction of food over 4–6 weeks) – with 1/6 partially completing it. Participant retention (four withdrawals) and data completeness (74%–100%) were acceptable and contamination low (two usual care participants had allergy tests). There were three minor SPT-related adverse events. During follow-up, 12 intervention and 8 usual care participants had minor, unrelated adverse events plus one unrelated hospital admission. Conclusions: it is possible to recruit, randomize and retain children with eczema from primary care into a trial of food allergy screening and to collect the outcomes of interest. Changes to recruitment and inclusion criteria are needed in a definitive trial, to ensure inclusion of younger children from more diverse backgrounds. |
| Databáze: | OpenAIRE |
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