Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2
| Autor: | Su-Kyung Lee, Byoung-Mog Kwon, Dong Cho Han, Jae Young Yang, Hyo Kon Chun, Kwang-Hee Son |
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| Rok vydání: | 2007 |
| Předmět: |
Matrix metalloproteinase inhibitor
Clinical Biochemistry Pharmaceutical Science Matrix Metalloproteinase Inhibitors Matrix metalloproteinase Biochemistry Cell Movement Cell Line Tumor Drug Discovery Humans Neoplasm Invasiveness Protease Inhibitors Molecular Biology biology Plant Extracts Chemistry Organic Chemistry Biological activity Cell migration biology.organism_classification Cell biology Plant Leaves Magnolia Cell culture Cancer cell Molecular Medicine HT1080 Magnolia obovata |
| Zdroj: | Bioorganic & Medicinal Chemistry. 15:4085-4090 |
| ISSN: | 0968-0896 |
| Popis: | Because the activation of matrix metalloproteinases (MMP) is a key factor in the metastatic process, compounds with the ability to inhibit MMP activity have a potential in the treatment of tumor. From the examination of 2000 plant extracts, obovatal isolated from the extract of the leaves of Magnolia obovata THUNB was a potent inhibitor of MMP-2 enzyme in vitro. In human fibrosarcoma cells (HT1080) activated with MMP-2, obovatal inhibited MMP-2 enzyme activity and expression. In addition, the compound blocked migration and invasion of the cells. This study demonstrates that obovatal exerts its anticancer effects through blocking migration and invasion by inhibition of MMP-2 expression and activity, and also will be a good lead molecule for the development of anti-tumor drug. |
| Databáze: | OpenAIRE |
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