Prolonging morbidity in rabid dogs by intrathecal injection of attenuated rabies vaccine
| Autor: | L. W. Williams, J H Shaddock, G M Baer |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Rabies
Immunology Fluorescent Antibody Technique Antibodies Viral Vaccines Attenuated Intrathecal Microbiology Neutralization Dogs Rabies vaccine Cerebrospinal fluid Neutralization Tests medicine Animals Injections Spinal Cerebrospinal Fluid Attenuated vaccine biology business.industry Brain medicine.disease Macaca mulatta Virology Infectious Diseases Rabies Vaccines Antibody Formation Inactivated vaccine biology.protein Cattle Parasitology Interferons Antibody business Research Article medicine.drug |
| Zdroj: | Infection and Immunity. 12:98-103 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.12.1.98-103.1975 |
| Popis: | Dogs vaccinated intrathecally with attenuated rabies vaccine developed antibodies that were detected in the cerebrospinal fluid, blood, and brain; dogs similarly vaccinated but with an inactivated vaccine developed no antibodies in the brain. When the attenuated vaccine was administered to rabid dogs, a prolongation of the morbidity period was noted and, in some dogs, recovery from the disease. Rhesus monkeys died when administered any of the available attenuated vaccines intrathecally, and further studies with that species could not be undertaken. |
| Databáze: | OpenAIRE |
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