Tandem Anionic oxy-Cope Rearrangement/Oxygenation Reactions as a Versatile Method for Approaching Diverse Scaffolds

Autor:	Ullrich Jahn, Ivana Císařová, Radek Pohl, Michal Šimek, Kateřina Bártová
Rok vydání:	2019
Předmět:	Tandem Chemistry Radical food and beverages Oxy-Cope rearrangement General Chemistry Oxygenation Radical cyclization Combinatorial chemistry Catalysis
Zdroj:	Angewandte Chemie (International ed. in English). 59(15)
ISSN:	1521-3773
Popis:	Tandem anionic oxy-Cope rearrangement/radical oxygenation reactions provide δ,ϵ-unsaturated α-(aminoxy) carbonyl compounds, which serve as convenient precursors to diverse compound classes. Functionalized carbocycles are accessible by very rare all-carbon 5-endo-trig cyclizations, but also common 5-exo-trig radical cyclizations, based on the persistent radical effect. The tandem reactions can be further extended by highly diastereoselective allylation or reduction steps to give complex scaffolds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace59c0dfb2041ef41ab778f22227e81 https://pubmed.ncbi.nlm.nih.gov/31994304 Zobrazit plný text záznamu Plný text