Early Clinical Experience With the TRICENTO Bicaval Valved Stent for Treatment of Symptomatic Severe Tricuspid Regurgitation: A Multicenter Registry
| Autor: | Mirjam G. Wild, Edith Lubos, Ignacio Cruz-Gonzalez, Ignacio Amat-Santos, Marco Ancona, Martin Andreas, Niklas F. Boeder, Christian Butter, Fernando Carrasco-Chinchilla, Rodrigo Estevez-Loureiro, Jörg Kempfert, Benedikt Köll, Matteo Montorfano, Holger M. Nef, Stefan Toggweiler, Axel Unbehaun, Paul Werner, Stephan Windecker, Fabien Praz |
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| Rok vydání: | 2022 |
| Předmět: |
Aged
80 and over Heart Valve Prosthesis Implantation Male Cardiac Catheterization Time Factors heart failure tricuspid valve heart valve diseases Severity of Illness Index Tricuspid Valve Insufficiency Treatment Outcome Humans stent Female Stents Registries Tricuspid Valve Cardiology and Cardiovascular Medicine Aged Retrospective Studies |
| Zdroj: | Circulation. Cardiovascular interventions. 15(3) |
| ISSN: | 1941-7632 |
| Popis: | Background: Patients with severe tricuspid regurgitation present late and are often ineligible for surgery or transcatheter repair systems. Transfemoral venous implantation of a bicaval valved stent has been proposed as therapeutic option in selected patients. The aim of this study was to summarize the early procedural and clinical outcomes of the novel TRICENTO system for the treatment of patients with symptomatic severe tricuspid regurgitation. Methods: All consecutive patients treated with the custom-made TRICENTO implant at the participating centers were included in this retrospective multicentre registry. Results: A total of 21 high-risk patients (mean age 76±7 years; 67% female) with severe or higher grade tricuspid regurgitation were analyzed. The majority of the patients were in New York Heart Association class III/IV (95%), had peripheral edema (95%), and previous hospitalization for right heart failure (67%). Technical success was 100%, and there was no case of in-hospital mortality. During follow-up (median 61 days), symptomatic improvement was observed (65% in New York Heart Association class I/II; P 3 at baseline versus 216±58 mm 3 at follow-up, P =0.006) of right ventricular end-diastolic volume. The overall-survival rate was 76% at 1 year. Conclusions: The present data indicate the feasibility of transfemoral bicaval valved stent implantation for the treatment of severe tricuspid regurgitation. Functional improvement and signs of right ventricular reverse remodeling were observed. Stent fractures did not impair valve function, but require refinement of prosthesis design and careful assessment of eligibility criteria. |
| Databáze: | OpenAIRE |
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