Improved Biocompatibility of Novel Biodegradable Scaffold Composed of Poly-L-lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery
| Autor: | Weiwang Gu, Jingyao Fan, Jianmin Xiao, Shihang Wang, Xiaoxin Zheng, Gaoke Feng, Jinxi Xia, Dongsheng Gu, Yuying Bi, Guanyang Kang, Zhicheng Huo, Qun Wang, Tim Wu, Xuejun Jiang, Zhimin Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Scaffold
Materials science Biocompatibility Article Subject Inflammation 02 engineering and technology 030204 cardiovascular system & hematology 021001 nanoscience & nanotechnology Nitric oxide Coronary arteries Vascular endothelial growth factor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry lcsh:Technology (General) medicine Biophysics lcsh:T1-995 General Materials Science Amorphous calcium phosphate medicine.symptom 0210 nano-technology Cell adhesion |
| Zdroj: | Journal of Nanomaterials, Vol 2016 (2016) |
| ISSN: | 1687-4129 1687-4110 |
| Popis: | Using poly-L-lactic acid for implantable biodegradable scaffold has potential biocompatibility issue due to its acidic degradation byproducts. We have previously reported that the addition of amorphous calcium phosphate improved poly-L-lactic acid coating biocompatibility. In the present study, poly-L-lactic acid and poly-L-lactic acid/amorphous calcium phosphate scaffolds were implanted in pig coronary arteries for 28 days. At the follow-up angiographic evaluation, no case of stent thrombosis was observed, and the arteries that were stented with the copolymer scaffold had significantly less inflammation and nuclear factor-κB expression and a greater degree of reendothelialization. The serum levels of vascular endothelial growth factor and nitric oxide, as well the expression of endothelial nitric oxide synthase and platelet-endothelial cell adhesion molecule-1, were also significantly higher. In conclusion, the addition of amorphous calcium phosphate to biodegradable poly-L-lactic acid scaffold minimizes the inflammatory response, promotes the growth of endothelial cells, and accelerates the reendothelialization of the stented coronary arteries. |
| Databáze: | OpenAIRE |
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