Prescription Claims for Immunomodulator and Antiinflammatory Drugs Among Persons With Ehlers-Danlos Syndromes

Autor:	Rebecca Bascom, Jane R. Schubart, Alan J. Hakim, Radha Dhingra, Clair A. Francomano
Rok vydání:	2021
Předmět:	Joint hypermobility Drug medicine.medical_specialty business.industry media_common.quotation_subject Private prescription Disease medicine.disease Rheumatology Internal medicine Cohort Epidemiology medicine Medical prescription business Rheumatism media_common
Zdroj:	Arthritis careresearchREFERENCES.
ISSN:	2151-4658 2005-2014
Popis:	OBJECTIVE Joint hypermobility in Ehlers-Danlos Syndromes (EDS) predisposes persons with EDS to frequent subluxations and dislocations, chronic arthralgia, and soft-tissue rheumatism. Epidemiological trends of rheumatologic conditions among persons with EDS are lacking. Prescription claims databases can reflect underlying disease burdens by utilizing medication claims as disease proxies. We examined the prevalence of prescription claims for commonly prescribed immunomodulator and anti-inflammatory (IMD) drugs among persons with EDS compared to their matched controls, and hypothesized peripubertal increases among females with EDS. METHODS We compared the percentages of IMD drug prescription claims among 3484 persons with EDS (aged 5-62) against their age-, sex-, state of residence-, and earliest claim date-matched controls using 10 years (2005-2014) of private prescription claims data, and a minimum two-year enrollment inclusion criterion. RESULTS Our cohort comprised 70% adults and 74% females. At least one IMD medication was prescribed to 65.4% persons with EDS compared to 47.4% controls. We observed 1.3 to 4.2 times higher odds (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace481e672e7658a4a7733fbba1e454c https://pubmed.ncbi.nlm.nih.gov/34788905 Zobrazit plný text záznamu Plný text