Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves' ophthalmopathy
| Autor: | Edson Nacib Jorge, Sandro José Conde, Célia Regina Nogueira, Sueli A. Clara, Renata de Azevedo Melo Luvizotto, Miriane de Oliveira, Maria Teresa De Sibio, Gláucia Maria Ferreira da Silva Mazeto, Vania dos Santos Nunes, Sarah Santiloni Cury |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism lcsh:Medicine Estrogen receptor Gene Expression Real-Time Polymerase Chain Reaction lcsh:Diseases of the endocrine glands. Clinical endocrinology Dexamethasone Pathogenesis Graves' ophthalmopathy Internal medicine Gene expression medicine Humans Receptor Glucocorticoids Cells Cultured lcsh:RC648-665 business.industry lcsh:R Estrogen Receptor alpha Fibroblasts medicine.disease Graves Ophthalmopathy Endocrinology Treatment Outcome Estrogen Female business Estrogen receptor alpha hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Archives of Endocrinology and Metabolism, Vol 59, Iss 3, Pp 273-276 SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 2359-4292 2359-3997 |
| Popis: | Made available in DSpace on 2015-08-26T19:19:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-01. Added 1 bitstream(s) on 2015-08-31T13:05:04Z : No. of bitstreams: 1 S2359-39972015000300273.pdf: 130120 bytes, checksum: 6dc2ae5dfe61f973ea9aecc7248da395 (MD5) Made available in DSpace on 2015-08-26T19:19:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-01. Added 1 bitstream(s) on 2015-08-31T13:05:04Z : No. of bitstreams: 1 S2359-39972015000300273.pdf: 130120 bytes, checksum: 6dc2ae5dfe61f973ea9aecc7248da395 (MD5) Made available in DSpace on 2015-08-26T19:19:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-01. Added 1 bitstream(s) on 2015-08-31T13:05:04Z : No. of bitstreams: 1 S2359-39972015000300273.pdf: 130120 bytes, checksum: 6dc2ae5dfe61f973ea9aecc7248da395 (MD5) Made available in DSpace on 2015-08-26T19:19:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-01. Added 1 bitstream(s) on 2015-08-31T13:05:04Z : No. of bitstreams: 1 S2359-39972015000300273.pdf: 130120 bytes, checksum: 6dc2ae5dfe61f973ea9aecc7248da395 (MD5) Made available in DSpace on 2015-08-26T19:19:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-06-01. Added 1 bitstream(s) on 2015-08-31T13:05:04Z : No. of bitstreams: 1 S2359-39972015000300273.pdf: 130120 bytes, checksum: 6dc2ae5dfe61f973ea9aecc7248da395 (MD5) Graves’ ophthalmopathy (GO) is one of the most severe clinical manifestations of Graves’ disease (GD), and its treatment might involve high-dose glucocorticoid therapy. The higher incidence of GO among females, and the reported association between polymorphisms of estrogen receptor (ER) and GD susceptibility have led us to question the role of estrogen and its receptor in GO pathogenesis. We, thus, assessed estrogen receptor-alpha (ERA) gene expression in cultures of orbital fibroblasts from a patient with GO before (controls) and after treatment with 10 nM and 100 nM dexamethasone (DEX). Orbital fibroblasts showed ERA gene expression. In the cells treated with 10 nM and 100 nM DEX, ERA gene expression was, respectively, 85% higher and 74% lower, than in the control group. We concluded that ERA gene expression is found in the orbital fibroblasts of patient with GO, which may be affected by glucocorticoids in a dose-related manner. Arch Endocrinol Metab. 2015;59(3):273-6 Sao Paulo State University Botucatu Medical School Internal Medicine Department Unesp Sao Paulo State University Botucatu Medical School Internal Medicine Department Unesp |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|