Detection of community‐acquired respiratory viruses in allogeneic stem‐cell transplant recipients and controls—A prospective cohort study
| Autor: | Stephanie Kurze, Toni Lamik, Beate Hermann, Maria Rüthrich, Nils Winkelmann, Anne Klink, Andreas Hochhaus, Jana Kalkreuth, Inken Hilgendorf, Pia Stier, Kathleen Wagner, Marie von Lilienfeld-Toal, Susanne Lang, Friedrich J. Hammersen, Tobias Rachow |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Mycoplasma pneumoniae medicine.medical_specialty Adolescent Coronaviridae medicine.medical_treatment medicine.disease_cause Adenoviridae Cohort Studies Young Adult Influenza A Virus H1N1 Subtype Risk Factors Throat Internal medicine Epidemiology Medicine Humans Transplantation Homologous Prospective Studies CARV Respiratory system Prospective cohort study Respiratory Tract Infections Aged Aged 80 and over Immunosuppression Therapy Transplantation immunosuppression Respiratory tract infections business.industry Immunosuppression Orignal Article Middle Aged Transplant Recipients Respiratory Syncytial Viruses Virus Shedding Community-Acquired Infections Infectious Diseases medicine.anatomical_structure Virus Diseases Female epidemiology business Stem Cell Transplantation |
| Zdroj: | Transplant Infectious Disease |
| ISSN: | 1399-3062 1398-2273 |
| Popis: | Background Community‐acquired respiratory viruses (CARV) cause upper and lower respiratory tract infections (URTI/LRTI) and may be life‐threatening for recipients of an allogeneic stem cell transplantation (allo‐SCT). Methods In a prospective study encompassing 4 winter‐seasons, we collected throat gargles (TG) at random time points from allo‐SCT recipients (patients) and controls and followed them up for at least 3 weeks including repetitive sampling and documentation of symptoms. A Multiplex‐PCR system to identify 20 CARV and Mycoplasma pneumoniae was used to detect CARV. Results One hundred ninety‐four patients with 426 TG and 273 controls with 549 TG were included. There were more patients with a positive test result (25% vs 11% in the controls), and the patients had a higher number of positive TG (70 = 16%) compared to controls (32 = 6%) (P 40 years (OR 3.38, 95% CI 1.8‐6.4, P |
| Databáze: | OpenAIRE |
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