Effects of n-3 Fatty Acids on Serum Interleukin-6, Tumour Necrosis Factor-α and Soluble Tumour Necrosis Factor Receptor p55 in Active Rheumatoid Arthritis
| Autor: | T Sundrarjun, S Angthararak, O Puchaiwatananon, U Udomsuppayakul, N Archararit, W Dahlan, S Chuncharunee, S Komindr |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Linoleic acid Arthritis Biochemistry Arthritis Rheumatoid Linoleic Acid Placebos chemistry.chemical_compound Fish Oils Double-Blind Method Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 medicine Humans Interleukin 6 chemistry.chemical_classification biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Biochemistry (medical) Fatty acid Cell Biology General Medicine Middle Aged medicine.disease Fish oil Dietary Fats Eicosapentaenoic acid C-Reactive Protein Treatment Outcome Endocrinology chemistry Receptors Tumor Necrosis Factor Type I Docosahexaenoic acid Rheumatoid arthritis Dietary Supplements Immunology biology.protein Female business |
| Zdroj: | Journal of International Medical Research. 32:443-454 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/147323000403200501 |
| Popis: | We investigated the effects of a low n-6 fatty acid (FA) diet supplemented with fish oil on serum pro-inflammatory cytokine concentrations and clinical variables in patients with active rheumatoid arthritis (RA). Sixty patients were randomly assigned to receive a diet low in n-6 FAs and n-3 FAs supplement (fish oil group), a diet low in n-6 FAs and placebo (placebo group), or no special diet or intervention (control group). Serum cytokines and clinical and biochemical variables were evaluated at baseline and various timepoints. At week 18 the fish oil group had significant reductions in linoleic acid, C-reactive protein (CRP) and soluble tumour necrosis factor receptor p55 (sTNF-R p55), and significant elevations in eicosapentaenoic acid and docosahexaenoic acid compared with baseline. There were no significant differences in the clinical variables between the three groups. At week 24 there were significant reductions in interleukin-6 and TNF-α in the fish oil and placebo groups. Supplementation with n-3 FA and a low n-6 FA intake decreased serum sTNF-R p55 and CRP levels in patients with RA. |
| Databáze: | OpenAIRE |
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