Protollin™: a novel adjuvant for intranasal vaccines
| Autor: | Sonya L. Cyr, David S. Burt, Nathalie Bellerose, Francine Allard, George H. Lowell, Taff Jones |
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| Rok vydání: | 2004 |
| Předmět: |
Lipopolysaccharides
Chemistry Pharmaceutical medicine.medical_treatment Hemagglutinin (influenza) Antibodies Viral Virus Mice Adjuvants Immunologic Orthomyxoviridae Infections Antigen Immunity medicine Animals Immunity Mucosal Administration Intranasal Drug Carriers Mice Inbred BALB C Vaccines Vaccines Synthetic General Veterinary General Immunology and Microbiology biology Public Health Environmental and Occupational Health Virology Immunoglobulin A Cysteine Endopeptidases Drug Combinations Hemagglutinins Infectious Diseases Immunization Influenza Vaccines Immunoglobulin G Liposomes Immunology biology.protein Cytokines Molecular Medicine Female Nasal administration Antibody Adjuvant Spleen |
| Zdroj: | Vaccine. 22:3691-3697 |
| ISSN: | 0264-410X |
| Popis: | Protollin is a novel adjuvant comprising Proteosomes non-covalently complexed with LPS. Intranasal immunization of mice with Protollin combined with detergent-split influenza antigens (HA) or recombinant influenza hemagglutinin (rHA) enhanced serum IgG and mucosal IgA levels by up to 250-fold compared with immunization with the antigens alone. IFN-gamma responses were also enhanced compared to the levels produced by splenocytes from mice immunized with antigen alone, while production of IL-5 was abrogated. Mice immunized with Protollin-rHA were completely protected against lethal challenge with influenza virus, demonstrating that Protollin is an effective mucosal adjuvant for prophylactic vaccines. |
| Databáze: | OpenAIRE |
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