Headspace Solid-Phase Microextraction Gas Chromatography-Mass Spectrometry Analysis of Scent Profiles from Human Skin
| Autor: | Aoife Morrin, Gwendoline Albero, Emer Duffy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Aging
human odour non-invasive Pharmaceutical Science Human skin Dermatology Solid-phase microextraction 01 natural sciences lcsh:Chemistry 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine volatile organic compounds Body odour medicine fragrance Chemical Engineering (miscellaneous) Chromatography integumentary system Chemistry 010401 analytical chemistry Non invasive Spectrum analysis 3. Good health 0104 chemical sciences lcsh:QD1-999 Surgery Gas chromatography–mass spectrometry medicine.symptom |
| Zdroj: | Cosmetics Volume 5 Issue 4 Duffy, Emer ORCID: 0000-0003-4557-6487 Cosmetics, Vol 5, Iss 4, p 62 (2018) |
| ISSN: | 2079-9284 |
| DOI: | 10.3390/cosmetics5040062 |
| Popis: | Volatile organic compounds (VOCs) emanating from human skin contribute to an individual&rsquo s body odour. Understanding the modulation of human odour by a fragrance is of significant importance to the cosmetic sector in the design, development and evaluation of new products. The present research describes an in vivo approach for passive headspace sampling of skin volatile emissions in human participants. A wearable headspace solid-phase microextraction (HS-SPME) method has been employed to investigate baseline endogenous skin volatiles and the subsequent modulation of skin volatile profiles after application of a fragrance to skin. Coupled with gas chromatography-mass spectrometry (GC-MS) this method enables characterisation of scent profiles and fragrance longevity in vivo. A total of 51 compounds were identified in participants&rsquo skin, including 19 endogenous and 32 fragrance-derived compounds. The temporal variation in volatile profiles at different times after fragrance application was investigated. Fragrance diffusion from skin varied between participants resulting in diversified scent profiles over time. This non-invasive approach could be employed during cosmetic product development for in vivo evaluation of fragrance profiles and for assessment of the retention of fragrance components in skin to reduce reliance on expert panels during product development. |
| Databáze: | OpenAIRE |
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