Characterization of non-linear mechanical behavior of the cornea
| Autor: | A. Ashofteh Yazdi, Guillermo Rus, Miguel Gonzalez-Andrades, Inas H. Faris, Jorge Torres, Antonio Callejas, Juan Melchor |
|---|---|
| Přispěvatelé: | [Ashofteh Yazdi,A, Torres,J, Faris,I, Callejas,A, Rus,G] Ultrasonics Lab, Department of Structural Mechanics, University of Granada, Politécnico de Fuentenueva, Granada, Spain. [Ashofteh Yazdi,A] Department of Biomedical Engineering, Islamic Azad University, Mashhad Branch, Mashhad, Iran. [Melchor,J] Department of Statistics and Operations Research, University of Granada, Granada, Spain. [Melchor,J, Rus,G] Instituto de Investigación Biosanitaria, Ibs.GRANADA, Granada, Spain. [Melchor,J, Rus,G] Excellence Research Unit, 'Modelling Nature' (MNat), University of Granada, Granada, Spain. [Gonzalez-Andrades,M] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Reina Sofia University Hospital and University of Cordoba, Edificio IMIBIC, Cordoba, Spain. [Gonzalez-Andrades,M] Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA., This research was supported by the Ministry of Education, DPI2017-83859-R, DPI2014-51870-R, EQC2018-004508-P and UNGR15-CE-3664, Ministry of Health DTS15/00093, and Junta de Andalucía PI16/00339, PI-0107-2017, and PIN-0030-2017 projects. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Swine
lcsh:Medicine Model parameters Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Mechanical Processes::Stress Mechanical [Medical Subject Headings] 02 engineering and technology Cornea 0302 clinical medicine Organisms::Eukaryota::Animals [Medical Subject Headings] lcsh:Science Phenomena and Processes::Physical Phenomena::Optical Phenomena::Anisotropy [Medical Subject Headings] Multidisciplinary Ogden Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Swine [Medical Subject Headings] Biomechanical Phenomena medicine.anatomical_structure Model parameter Anatomy::Sense Organs::Eye::Anterior Eye Segment::Cornea [Medical Subject Headings] Biomedical engineering Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Theoretical::Nonlinear Dynamics [Medical Subject Headings] Coefficient of determination Materials science Corneal diseases 0206 medical engineering Chemicals and Drugs::Inorganic Chemicals::Hydroxides::Sodium Hydroxide [Medical Subject Headings] Article 03 medical and health sciences Diseases::Wounds and Injuries::Burns::Burns Chemical [Medical Subject Headings] Fenómenos biomecánicos Tensile Strength Ultimate tensile strength Burns Chemical medicine Animals Sodium Hydroxide Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Elasticity [Medical Subject Headings] Dinámicas no lineales lcsh:R Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Tensile Strength [Medical Subject Headings] Diagnostic markers 020601 biomedical engineering Porcinos Elasticity Córnea Nonlinear system Nonlinear Dynamics Hyperelastic material Animales 030221 ophthalmology & optometry Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Biomechanical Phenomena [Medical Subject Headings] Anisotropy lcsh:Q sense organs Stress Mechanical |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Digibug. Repositorio Institucional de la Universidad de Granada instname |
| Popis: | The objective of this study was to evaluate which hyperelastic model could best describe the nonlinear mechanical behavior of the cornea, in order to characterize the capability of the non-linear model parameters to discriminate structural changes in a damaged cornea. Porcine corneas were used, establishing two diferent groups: control (non-treated) and NaOH-treated (damaged) corneas (n= 8). NaOH causes a chemical burn to the corneal tissue, simulating a disease associated to structural damage of the stromal layer. Quasi-static uniaxial tensile tests were performed in nasaltemporal direction immediately after preparing corneal strips from the two groups. Three non-linear hyperelastic models (i.e. Hamilton-Zabolotskaya model, Ogden model and Mooney-Rivlin model) were ftted to the stress–strain curves obtained in the tensile tests and statistically compared. The corneas from the two groups showed a non-linear mechanical behavior that was best described by the Hamilton-Zabolotskaya model, obtaining the highest coefcient of determination (R2 > 0.95). Moreover, Hamilton-Zabolotskaya model showed the highest discriminative capability of the nonlinear model parameter (Parameter A) for the tissue structural changes between the two sample groups (p= 0.0005). The present work determines the best hyperelastic model with the highest discriminative capability in description of the non-linear mechanical behavior of the cornea. Ministry of Education DPI2017-83859-R DPI2014-51870-R EQC2018004508-P UNGR15-CE-3664 Ministry of Health - Turkey DTS15/00093 Junta de Andalucia PI16/00339 PI-0107-2017 PIN-0030-2017 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|