Body Composition, Cardiorespiratory Fitness, and Low-Grade Inflammation in Middle-Aged Men and Women
Autor: | Claude Bouchard, Jean-Pierre Després, Amélie Cartier, Mélanie Côté, Isabelle Lemieux, Louis Pérusse, Benoit J. Arsenault, Angelo Tremblay |
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Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Intra-Abdominal Fat Statistics as Topic Physical fitness Adipose tissue Physiology Body Mass Index Cardiovascular Physiological Phenomena Insulin resistance Internal medicine medicine Health Status Indicators Humans Inflammation Exercise Tolerance Adiponectin biology Tumor Necrosis Factor-alpha business.industry Interleukins C-reactive protein Cardiorespiratory fitness Middle Aged medicine.disease C-Reactive Protein Endocrinology Physical Fitness Area Under Curve Body Composition Respiratory Physiological Phenomena biology.protein Cardiology Female Insulin Resistance Cardiology and Cardiovascular Medicine business Body mass index Biomarkers |
Zdroj: | The American Journal of Cardiology. 104:240-246 |
ISSN: | 0002-9149 |
DOI: | 10.1016/j.amjcard.2009.03.027 |
Popis: | The objective of the present study was to determine the respective contributions of visceral adipose tissue (AT) accumulation and cardiorespiratory fitness to variation of inflammatory markers in men and women. Circulating levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and adiponectin were obtained with visceral AT (computed tomography) and fitness (physical working capacity test) levels in a sample of healthy men (n = 120) and women (n = 152) covering a wide range of adiposity. An inflammation score was developed based on gender-specific percentile values of each inflammatory marker (0 or 1), which yielded a score ranging from 0 (low) to 4 (high). Visceral AT was positively associated with C-reactive protein and interleukin-6 levels (ror =0.35, p0.0001), but negatively associated with adiponectin (r = -0.29, por =0.0003) after adjustment for fitness. After adjusting for visceral AT, fitness was not associated with variation in inflammatory markers in women and only with adiponectin in men (r = -0.20, p = 0.03). In participants with low visceral AT (130 cm(2) for men and100 cm(2) for women), prevalences of participants with an increased inflammation score were 23.9% and 28.0%, respectively, for participants with high and low fitness, whereas in subjects with increased visceral AT, prevalences of a high inflammation score were 60.0% and 61.7%, respectively, for participants with high and low fitness. In conclusion, these results suggest that the previously reported association between poor fitness and low-grade inflammation may be largely attributable to increased visceral AT accumulation and its associated state of insulin resistance, conditions frequently observed in subjects with poor cardiorespiratory fitness. |
Databáze: | OpenAIRE |
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