Influenza vaccination and cardiovascular risk in patients with recent TIA and stroke
| Autor: | Pierre Amarenco, Philippe Gabriel Steg, Philippa C. Lavallée, Pablo M. Lavados, Kim M. Fox, Heinrich Mattle, Julien Labreuche |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction 610 Medicine & health Cohort Studies Risk Factors Internal medicine medicine Humans Myocardial infarction Prospective Studies cardiovascular diseases Prospective cohort study Stroke Aged Randomized Controlled Trials as Topic business.industry Hazard ratio Vaccination Middle Aged medicine.disease Confidence interval Surgery Cardiovascular Diseases Influenza Vaccines Ischemic Attack Transient Cohort Female Neurology (clinical) business Cohort study |
| Zdroj: | Lavallée, Philippa C.; Labreuche, Julien; Fox, Kim M.; Lavados, Pablo; Mattle, Heinrich; Steg, Philippe Gabriel; Amarenco, Pierre (2014). Influenza vaccination and cardiovascular risk in patients with recent TIA and stroke. Neurology, 82(21), pp. 1905-1913. Lippincott Williams & Wilkins 10.1212/WNL.0000000000000456 |
| Popis: | Objectives: To determine whether current influenza vaccination is associated with reduced risk of major vascular events in patients with recent ischemic stroke or TIA of mainly atherothrombotic origin. Methods: Data were pooled from 2 prospective cohort studies, the OPTIC Registry (n = 3,635) and the AMISTAD Study (n = 618), and from the randomized PERFORM Trial (n = 19,120), all of which included patients with recent ischemic stroke or TIA. Influenza vaccination status was determined in 23,110 patients. The primary outcome was a composite of nonfatal myocardial infarction, nonfatal stroke, or vascular death up to 2 years. Secondary outcomes were myocardial infarction and stroke separately. Results: Influenza vaccination had no association with the primary outcome in the propensity score–matched cohort (hazard ratio 0.97, 95% confidence interval [CI] 0.85–1.11; p = 0.67) or in the propensity score–adjusted cohort (hazard ratio 1.00, 95% CI 0.89–1.12; p = 0.99). Similarly, the risk of stroke and myocardial infarction did not differ between the vaccinated group and the unvaccinated group; in the matched cohort, the hazard ratio was 1.01 (95% CI 0.88–1.17; p = 0.89) for stroke and 0.84 (95% CI 0.59–1.18; p = 0.30) for myocardial infarction. Conclusions: Influenza vaccination was not associated with reduced outcome events in patients with recent atherothrombotic ischemic stroke after considering all baseline characteristics (including concomitant medications) associated with influenza vaccination. |
| Databáze: | OpenAIRE |
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