Modeling of oscillatory bursting activity of pancreatic beta-cells under regulated glucose stimulation
| Autor: | Yoke Lin Shia, Yin Hoon Chew, Mohamad Roji Sarmidi, Fadzilah Adibah Abdul Majid, Chew Tin Lee, Ramlan Aziz, Lee Suan Chua |
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| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.medical_treatment Biology Models Biological Biochemistry Bursting Endocrinology Insulin-Secreting Cells Internal medicine Diabetes mellitus Glucokinase medicine Extracellular Animals Molecular Biology geography geography.geographical_feature_category Insulin Islet medicine.disease Cell biology Glucose Postprandial Blood sugar regulation Extracellular Space |
| Zdroj: | Molecular and Cellular Endocrinology. 307:57-67 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2009.03.005 |
| Popis: | A mathematical model to describe the oscillatory bursting activity of pancreatic beta-cells is combined with a model of glucose regulation system in this work to study the bursting pattern under regulated extracellular glucose stimulation. The bursting electrical activity in beta-cells is crucial for the release of insulin, which acts to regulate the blood glucose level. Different types of bursting pattern have been observed experimentally in glucose-stimulated islets both in vivo and in vitro, and the variations in these patterns have been linked to changes in glucose level. The combined model in this study enables us to have a deeper understanding on the regime change of bursting pattern when glucose level changes due to hormonal regulation, especially in the postprandial state. This is especially important as the oscillatory components of electrical activity play significant physiological roles in insulin secretion and some components have been found to be lost in type 2 diabetic patients. |
| Databáze: | OpenAIRE |
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