Evaluation of medication dose adjustments in patients with impaired renal function using different online drug information databases
| Autor: | Betül Okuyan, Refik Demirtunç, Oznur Altiparmak, Aysenur Altan, Fikret Izzettin, Mesut Sancar |
|---|---|
| Přispěvatelé: | İZZETTİN, Fikret Vehbi |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Databases Factual media_common.quotation_subject Renal function Fleiss' kappa computer.software_genre Kidney Pharmacists 030226 pharmacology & pharmacy Clinical decision support system 03 medical and health sciences Impaired renal function 0302 clinical medicine Pharmacotherapy science and practice 2020 [Sancar M. Altiparmak O. Altan A. Demirtunc R. Izzettin F. V. Okuyan B. -Evaluation of medication dose adjustments in patients with impaired renal function using different online drug information databases.- European journal of hospital pharmacy] Medicine Humans 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics media_common Aged Retrospective Studies Aged 80 and over Database business.industry Retrospective cohort study Middle Aged Decision Support Systems Clinical Clinical pharmacy business computer |
| Zdroj: | European journal of hospital pharmacy : science and practice. 29(5) |
| ISSN: | 2047-9956 |
| Popis: | Clinical pharmacist-led medication dose adjustment is required to provide safe and effective pharmacotherapy in patients with impaired renal function. This study aimed to assess clinical pharmacist-led medication dose adjustments in hospitalised patients with impaired renal function by comparing three online drug information databases.This retrospective observational study was conducted in an internal medicine ward between November 2016 and February 2017 among hospitalised patients with at least one estimated glomerular filtration rate (eGFR) valuelt;60 mL/min/1.73 msup2/sup. Clinical pharmacist-led medication dose adjustments according to eGFR were performed by comparing three online drug information databases: Micromedex, Medscape and Lexicomp. The number of items related to dose adjustments detected during the study period and the concordance between databases were evaluated.This study was conducted among 100 hospitalised patients (mean age 74.6±13.2 years) with impaired renal function. Clinical pharmacists detected at least one medication dose adjustment in 71.0% of patients. Among these patients, it was found that physician-led medication dose adjustments were made in only 15.5% of them. Of 1053 medications, the number of medications that required dose adjustments were 149 (14.2%), 151 (14.3%) and 163 (15.5%) according to Micromedex, Medscape and Lexicomp, respectively. The Fleiss kappa coefficient was 0.875 and the agreement of the three clinical decision support systems were almost perfect.In renal dose adjustments, Micromedex, Lexicomp and Medscape are concordant as online drug information databases. Clinical pharmacists could detect medication dose adjustment requirements in hospital patients with impaired renal function. The potential positive impact of clinical pharmacist-led medication dose adjustment should be investigated in further studies. |
| Databáze: | OpenAIRE |
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