Anxiolytic effects of a galacto‑oligosaccharides prebiotic in healthy females (18–25 years) with corresponding changes in gut bacterial composition
| Autor: | Arjen Nauta, Nicola Johnstone, Kathrin Cohen Kadosh, Chiara Milesi, Bartholomeus van den Bogert, Olivia Burn, Paul T. Sowden, Philip W.J. Burnet, Kathryn Hart |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Nutritional Supplementation Adolescent medicine.medical_treatment Science Attentional bias Gut flora Anxiety Placebo Article law.invention 03 medical and health sciences Probiotic Young Adult 0302 clinical medicine law Human behaviour medicine Humans Multidisciplinary biology business.industry Prebiotic Microbiota biology.organism_classification Healthy Volunteers Gastrointestinal Microbiome 030104 developmental biology Mood Prebiotics Anti-Anxiety Agents Dietary Supplements Medicine Female medicine.symptom business Trisaccharides 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| Popis: | Current research implicates pre- and probiotic supplementation as a potential tool for improving symptomology in physical and mental ailments, which makes it an attractive concept for clinicians and consumers alike. Here we focus on the transitional period of late adolescence and early adulthood during which effective interventions, such as nutritional supplementation to influence the gut microbiota, have the potential to offset health-related costs in later life. We examined multiple indices of mood and well-being in 64 healthy females in a 4-week double blind, placebo controlled galacto-oligosaccharides (GOS) prebiotic supplement intervention and obtained stool samples at baseline and follow-up for gut microbiota sequencing and analyses. We report effects of the GOS intervention on self-reported high trait anxiety, attentional bias, and bacterial abundance, suggesting that dietary supplementation with a GOS prebiotic may improve indices of pre-clinical anxiety. Gut microbiota research has captured the imagination of the scientific and lay community alike, yet we are now at a stage where this early enthusiasm will need to be met with rigorous research in humans. Our work makes an important contribution to this effort by combining a psychobiotic intervention in a human sample with comprehensive behavioural and gut microbiota measures. |
| Databáze: | OpenAIRE |
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