Nasal endoscopic and CT scan alterations of the paranasal sinuses as predictors of severity in patients with cystic fibrosis
| Autor: | Claudia de Castro e Silva, Ângela Elizabeth de Holanda Araújo Freitas, Déborah Nogueira Vasconcelos, José Holanda Maia Filho, Marcos Rabelo de Freitas |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent sinusitis Computed tomography Cystic fibrosis Gastroenterology cystic fibrosis Young Adult Nasal Polyps Internal medicine Paranasal Sinuses medicine Humans severity of illness index Nasal polyps In patient Prospective Studies Child Prospective cohort study Inverse correlation Sinus (anatomy) medicine.diagnostic_test business.industry Endoscopy medicine.disease Surgery Cross-Sectional Studies medicine.anatomical_structure Paranasal sinuses Otorhinolaryngology Chronic Disease Female Tomography X-Ray Computed business |
| Zdroj: | Brazilian Journal of Otorhinolaryngology. (4):480-486 |
| ISSN: | 1808-8694 |
| DOI: | 10.5935/1808-8694.20130086 |
| Popis: | Cystic Fibrosis (CF) results from mutation in the transmembrane conductance regulator gene, responsible for controlling secretory processes. The upper airways (UA) are usually involved in the form of chronic pansinusitis. OBJECTIVE: To evaluate UA changes in patients with CF and to establish the correlations between sinonasal CT and endoscopic endonasal findings and disease severity. METHOD: Cross-sectional and prospective study with 20 patients older than 5 years with CF, assessing the Shwachman-Kulczycki (S-K) score, paranasal sinus tomography (CT) (Lund-Mackay score) and nasal endoscopy (Meltzer score). RESULTS: CT scan alterations were observed in 94% of cases. Endoscopic alterations findings in the upper airways were found in 10 patients. Nasal polyps were found in 3 patients (15%). There was a correlation between the intensity of changes on the CT and S-K score (p = 0.0097), and between endoscopic findings and S-K score (p = 0.0318). There was a positive correlation between the presence of chronic colonization and endoscopic findings (p = 0.0325), which was not observed on the CT (p = 0.2941). CONCLUSION: There is an inverse correlation between the S-K clinical score and nasal endoscopy and CT findings. Therefore, patients who are clinically more severe according to the S-K score have greater UA involvement. |
| Databáze: | OpenAIRE |
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