Water-Clear Cell Parathyroid Adenoma Causing Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Report of a Case
| Autor: | Hitomi Kodama, Masatoshi Iihara, Takahiro Okamoto, Takao Obara |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Hyperparathyroidism
Pathology medicine.medical_specialty Neurofibromatosis 1 Adolescent endocrine system diseases medicine.diagnostic_test business.industry General Medicine Hyperparathyroidism Primary medicine.disease Scintigraphy Parathyroid Neoplasms Surgical oncology medicine Humans Female Surgery Neurofibromatosis business Pathological Clear cell Primary hyperparathyroidism Ultrasonography Parathyroid adenoma |
| Zdroj: | Surgery Today. 37:884-887 |
| ISSN: | 1436-2813 0941-1291 |
| Popis: | Water-clear cell parathyroid adenoma is an exceedingly rare tumor, composed exclusively of tumor cells with abundant foamy cytoplasm. A combination of hyperparathyroidism and neurofibromatosis type 1 (NF1) is also a rare phenomenon. We report an 18-year-old woman with primary hyperparathyroidism caused by water-clear cell parathyroid adenoma in association with NF1. She had renal stones, hypercalcemia, and an elevated plasma level of intact parathyroid hormone. Physical examination revealed a palpable tumor in the right neck, and café-au-lait spots distributed over her entire body. An ultrasound examination showed an isoechoic mass in the right thyroid lobe. Thallium-technetium subtraction scintigraphy showed high thallium accumulation in the right thyroid lobe area. A surgical exploration revealed the palpable mass to be a parathyroid tumor. The pathological features were consistent with water-clear parathyroid adenoma. This is the first reported case of water-clear cell parathyroid adenoma associated with NF1. |
| Databáze: | OpenAIRE |
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