Association of vitamin D receptor polymorphisms with osteoporosis in mexican postmenopausal women
| Autor: | Rubén Lisker, Ricardo Correa-Rotter, Sergio Sanchez, Osvaldo Mutchinick, Sergio Ponce de Leon Rosales, Salomón Jasqui, María Aranda López |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Genotype Osteoporosis Calcitriol receptor Internal medicine Genetics medicine Humans Deoxyribonucleases Type II Site-Specific Mexico Genetics (clinical) Ecology Evolution Behavior and Systematics Osteoporosis Postmenopausal Aged Bone mineral Postmenopausal women Polymorphism Genetic business.industry Confounding Odds ratio Middle Aged medicine.disease Confidence interval Endocrinology Case-Control Studies Receptors Calcitriol Female business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0018-7143 |
| Popis: | 1 * Abstract It has been reported that Vitamin D receptor polymorphisms are associated with osteoporosis, particularly those demonstrated by the BsmI and Fok I restriction enzymes. Herein we report the results of a case-control study performed in postmenopausal Mexican women. We studied 65 osteo- porotic women (≤ -2.5 SD bone mineral density (BMD) of young normal fe- males) and 57 controls (over 90% ≥ -1.5 SD BMD of young normal females. Restriction enzymes BsmI and Fok I were used to identify polymorphisms. Odds ratios and their 95% confidence intervals were calculated, and analysis was performed controlling for age as a covariate. The BsmI genotypes re- vealed a higher frequency of the bb genotype in cases than in controls, con- tradicting much of the literature that suggests this genotype protects females against osteoporosis. Regarding the Fok I genotypes, we were unable to con- firm that the FF genotype has a protective effect against osteoporosis. The in- consistencies found in the literature and the results obtained in the present work suggest to us that other genetic and nongenetic factors are involved in the occurrence of osteoporosis, confounding the results of the possible asso- ciation of osteoporosis and VDR polymorphisms. |
| Databáze: | OpenAIRE |
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