Association of early protein intake and pre-peritoneal fat at five years of age: Follow-up of a randomized clinical trial

Autor: D. Gruszfeld, M. Weber, K. Gradowska, P. Socha, V. Grote, A. Xhonneux, E. Dain, E. Verduci, E. Riva, R. Closa-Monasterolo, J. Escribano, B. Koletzko, J. Beyer, M. Fritsch, G. Haile, U. Handel, I. Hannibal, S. Kreichauf, I. Pawellek, S. Schiess, S. Verwied-Jorky, R. von Kries, N. Ferré, M. Gispert-Llaurado, V. Luque, M.C. Rubio-Torrents, M. Zaragoza-Jordana, R. Janas, A. Wierzbicka, A. Stolarczyk, J. Socha, J.N. Van Hees, J. Hoyos, F. Martin, P. Poncelet, E. Perrin, C. Agostoni, M. Giovannini, A. Re Dionigi, S. Scaglioni, F. Vecchi, C. Arriza
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Pediatric Obesity
medicine.medical_specialty
Time Factors
Intra-Abdominal Fat
Endocrinology
Diabetes and Metabolism
Subcutaneous Fat
Nutritional Status
Medicine (miscellaneous)
Adipose tissue
030209 endocrinology & metabolism
CHOP
Childhood obesity
law.invention
03 medical and health sciences
Child Development
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
law
Internal medicine
Diet
Protein-Restricted
Humans
Medicine
Mass index
Infant Nutritional Physiological Phenomena
Adiposity
Ultrasonography
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Age Factors
Infant
Newborn
Infant
medicine.disease
Infant Formula
Europe
Endocrinology
Infant formula
Child
Preschool
Female
Observational study
Dietary Proteins
Peritoneum
Cardiology and Cardiovascular Medicine
business
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 26:824-832
ISSN: 0939-4753
Popis: Background and aims The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. Methods and results Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95%CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. Conclusions Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences.
Databáze: OpenAIRE
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