Neurological toxicity due to antimonial treatment for refractory visceral leishmaniasis
| Autor: | Misericordia Veciana de las Heras, Sergio Martínez Yélamos, Jordi Pedro Pérez, Marta Maristany Bosch, Nuria Sabé Fernández, Guillermo Cuervo, Elisabeth Matas Martín |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Myoclonus
Neurosciences. Biological psychiatry. Neuropsychiatry Case Report Therapeutics Electroencephalography Drug toxicity 03 medical and health sciences 0302 clinical medicine Refractory Sodium stibogluconate Leishmaniosi Physiology (medical) Toxicitat dels medicaments Neurotoxicity Medicine Beta Rhythm Adverse effect Leishmaniasis Beta activity medicine.diagnostic_test business.industry Antimonials food and beverages 030208 emergency & critical care medicine Terapèutica medicine.disease Visceral leishmaniasis Neurology Anesthesia Toxicity Antimonial Meglumine antimoniate Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Clinical Neurophysiology Practice Clinical Neurophysiology Practice, Vol 6, Iss, Pp 164-167 (2021) Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 2467-981X |
| Popis: | Highlights • Severe but reversible neurological toxicity due to antimonial treatment is rarely described. • Extrapyramidal symptoms and epileptogenic discharges can be observed. • EEG recordings are required to diagnose possible antimonial neurotoxicity. Introduction Although pentavalent antimonials are no longer considered the first-line therapy for visceral leishmaniasis in the developed world, they are still used in certain geographical areas and in refractory cases. These drugs have a great number of adverse effects; however, neurological toxicity has been rarely reported. Case report We present a 56-year-old woman who required long-term treatment with antimonial drugs due to refractory visceral leishmaniasis and presented clinically with tremor of extremities, myoclonus, gait disturbances and epileptic seizures. The EEG showed increased beta rhythms and generalized epileptogenic activity. She had a slow but favorable response after the withdrawal of antimonials and the initiation of anticonvulsant therapy. Conclusion Severe but reversible neurological toxicity is a rare adverse effect of prolonged antimonial treatment. More EEG record data are needed to support the suspicion of a possible increase of beta rhythms in this situation. |
| Databáze: | OpenAIRE |
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