Measurement of Inclusion Complex Formation between Cyclophane and Biological Relevant Amino Acids Using Electrospray Ionization, Cold-Spray Ionization and Fast Atom Bombardment Mass Spectrometry
| Autor: | Yumiko Kimura, Kentaro Yamaguchi, Muneharu Miyake, Koichi Metori, Yoshihisa Sei, Tomoyuki Ozawa |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Electrospray ionization Analytical chemistry General Chemistry General Medicine Spectrometry Mass Fast Atom Bombardment Fast atom bombardment Mass spectrometry Ion Amino acid chemistry.chemical_compound Piperidines chemistry Ethers Cyclic Stability constants of complexes Ionization Drug Discovery Amino Acids Cyclophane |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 53:1029-1033 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.53.1029 |
| Popis: | The investigation of the host-guest complex formations between cyclophane (TGDMAP) (1) as a host and L-acidic amino acids such as L-glutamic acid (Glu) and L-aspartic acid (Asp) as guests was carried out using fast atom bombardment (FAB), electrospray ionization (ESI) and cold-spray ionization (CSI) mass spectrometry (MS). The stability constant (K(s)) values obtained by the three different MS methods almost agreed. However, the complex ion peaks of a novel cyclophane (CPCn) (2) with Glu and Asp were not observed in FAB-MS. Then, these host-guest complex formations by use of CSI-MS and ESI-MS was examined, as the results, these complex ion peaks were observed clearly and the measurement values by the two MS methods are mostly in agreement. It was concluded that ESI-MS and CSI-MS are available for the determination of K(s) value as well as FAB-MS. |
| Databáze: | OpenAIRE |
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