Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses
| Autor: | João Ricardo Sato, Ana Paula Arantes Bueno, Keila Rebello, Michael Hornberger, Walter H. L. Pinaya, Leonardo Cruz de Souza |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Cerebellum Rest Biology 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine medicine Humans 0501 psychology and cognitive sciences Amyotrophic lateral sclerosis Default mode network Brain Mapping medicine.diagnostic_test Resting state fMRI General Neuroscience Homogeneity (statistics) Amyotrophic Lateral Sclerosis 05 social sciences Amplitude of low frequency fluctuations Brain Cognition medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Female Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Connectivity. 9:356-364 |
| ISSN: | 2158-0022 2158-0014 |
| DOI: | 10.1089/brain.2019.0663 |
| Popis: | Resting-state functional magnetic resonance imaging has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of nondemented ALS patients compared with healthy controls. As expected, we found the sensorimotor network with changes in fALFF and ReHo, and also found the default mode network (DMN), frontoparietal network (FPN), and salience network (SN) altered and the cerebellum, although no structural changes between ALS patients and controls were reported in the regions with fALFF and ReHo changes. We show an altered pattern in the spontaneous low-frequency oscillations that is not confined to the motor areas and reveal a more widespread involvement of nonmotor regions, including those responsible for cognition. |
| Databáze: | OpenAIRE |
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