Prevalence of Helicobacter pylori cagA, babA2, and dupA genotypes andcorrelation with clinical outcome in Malaysian patients with dyspepsia
| Autor: | Dzulkarnaen Zakaria Andee, Bin Alwi Zilfalil, Noorizan Abdul Majid, Habsah Hasan, Hussein Ali Osman, Syed Hassan, Rapeah Suppian |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Virulence Factors Virulence Disease Gastroenterology Helicobacter Infections Correlation Bacterial Proteins Health Care Sciences and Services Internal medicine Genotype medicine Ethnicity Prevalence CagA Humans Prospective Studies Dyspepsia Helicobacter pylori cagA babA2 dupA ethnicity virulence genes Sağlık Bilimleri ve Hizmetleri Prospective cohort study Aged Antigens Bacterial biology Helicobacter pylori business.industry Stomach Malaysia General Medicine Middle Aged biology.organism_classification bacterial infections and mycoses medicine.anatomical_structure Immunology Female business |
| Zdroj: | Volume: 45, Issue: 4 940-946 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: The severity of disease outcome in dyspepsia has been attributed to Helicobacter pylori virulence genes. The aim of this study was to determine the distribution of H. pylori virulence genes (cagA, babA2, and dupA) and to determine whether or not there arises a significant correlation with clinical dyspepsia outcomes. Materials and methods: H. pylori genotypes cagA, babA2, and dupA were identified by polymerase chain reactions from gastric biopsy samples in 105 H. pylori-positive patients. Results: The positive rates for cagA, babA2, and dupA genes in H. pylori dyspeptic patients were 69.5%, 41.0%, and 22.9%, respectively. cagA was more prevalent in Indians (39.7%), babA2 was more prevalent in Malays (39.5%), and dupA detection occurred more frequently in both Indians and Malays and at the same rate (37.5%). The Chinese inhabitants had the lowest prevalence of the three genes. Nonulcer disease patients had a significantly higher distribution of cagA (76.7%), babA2 (74.4%), and dupA (75.0%). There was no apparent association between these virulence genes and the clinical outcomes. Conclusion: The lower prevalence of these genes and variations among different ethnicities implies that the strains are geographically and ethnically dependent. None of the virulence genes were knowingly beneficial in predicting the clinical outcome of H. pylori infection in our subjects. |
| Databáze: | OpenAIRE |
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