Nonclinical Tools to Assess Risk of Drug Hypersensitivity Reactions
| Autor: | S. Casinghino, Jessica Whritenour, X. Zhu, M. Collinge |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology Drug Drug-Related Side Effects and Adverse Reactions Mechanism (biology) business.industry media_common.quotation_subject Toxicology Bioinformatics Risk Assessment Drug Hypersensitivity Small Molecule Libraries Toxicology studies 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Animals Humans Medicine Drug reaction business Risk assessment media_common |
| Zdroj: | Annual Review of Pharmacology and Toxicology. 56:561-576 |
| ISSN: | 1545-4304 0362-1642 |
| DOI: | 10.1146/annurev-pharmtox-010715-103354 |
| Popis: | The term drug hypersensitivity refers to a category of adverse drug reactions mediated by various immunological and nonimmunological mechanisms. Small-molecule drugs and biotherapeutics have been associated with drug hypersensitivity reactions (DHRs), and the mechanisms driving the responses vary. Depending on the mechanism, some DHRs may be detected in nonclinical toxicology studies, and there may be tools and models in place that can be used as part of a risk assessment strategy. In contrast, for other mechanisms, particularly those that are not readily detected during nonclinical development, predictive tools and strategies for risk assessment are not well defined. This chapter provides an overview of the nonclinical tools currently available to assess the risk for developing DHRs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|