Changes in maps of language function and the integrity of the arcuate fasciculus after therapy for chronic aphasia

Autor:	Andrew C. Papanicolaou, Jenifer Juranek, Joshua I. Breier
Rok vydání:	2011
Předmět:	Male medicine.medical_specialty Neuropsychological Tests Audiology Brain mapping Functional Laterality Article Lateralization of brain function White matter Arts and Humanities (miscellaneous) Parietal Lobe Aphasia Neural Pathways medicine Humans Arcuate fasciculus Stroke Aphasia Broca Brain Mapping Language Tests medicine.diagnostic_test Magnetoencephalography Infarction Middle Cerebral Artery Recovery of Function Middle Aged medicine.disease Temporal Lobe Frontal Lobe Functional imaging Diffusion Tensor Imaging medicine.anatomical_structure Language Therapy Neurology (clinical) medicine.symptom Psychology Cognitive psychology
Zdroj:	Neurocase. 17:506-517
ISSN:	1465-3656 1355-4794
Popis:	A patient with chronic aphasia secondary to unilateral stroke in the left hemisphere underwent language testing, diffusion tensor imaging (DTI), and functional imaging using magnetoencephalography (MEG) at four time points: 3 weeks prior to, immediately prior to, immediately after, and 3 months after Constraint Induced Language Therapy (CILT). Performance on language tests involving visual naming and repetition of spoken sentences improved between the immediately prior to and immediately after CILT testing sessions, but not between the pre-CILT sessions. MEG activation in putative pre-morbid language areas of the left hemisphere and homotopic areas of the right hemisphere increased immediately after therapy, as did integrity within the arcuate fasciculus bilaterally. These changes were not evident between the two pre-CILT sessions. While some of these functional, neurophysiological and structural changes had regressed 3 months after therapy, all remained at or above baseline levels. Results provide evidence for an association between improvement in functional status and the increased integrity within a white matter tract known to be involved in language function and its contralateral homologue, as well as increased neurophysiological activity in areas that have the potential to subserve language function bilaterally.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc7fe6354c1195e96f9ffba3e7b71ab https://doi.org/10.1080/13554794.2010.547505 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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