CD4+T Cells Programmed to Traffic to Lymph Nodes Account for Increases in Numbers of CD4+T Cells Up to 1 Year after the Initiation of Highly Active Antiretroviral Therapy for Human Immunodeficiency Virus Type 1 Infection
| Autor: | B M Jones, M. Susan Kennedy, M. Hubbard, J. Steven McDougal, Richard L. Hengel |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
CD4-Positive T-Lymphocytes
Anti-HIV Agents T cell Lymphocyte HIV Infections Biology Immunophenotyping Cohort Studies NAD+ Nucleosidase Antigen Antigens CD medicine Humans Immunology and Allergy L-Selectin ADP-ribosyl Cyclase Lymph node Membrane Glycoproteins T lymphocyte Viral Load Flow Cytometry ADP-ribosyl Cyclase 1 Antigens Differentiation Virology CD4 Lymphocyte Count Infectious Diseases medicine.anatomical_structure Immunology HIV-1 Lymph Nodes Lymph Viral load |
| Zdroj: | The Journal of Infectious Diseases. 184:93-97 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/320997 |
| Popis: | Cells programmed to traffic through lymph nodes dominate initial increases in total CD4(+) T cell numbers after highly active antiretroviral therapy (HAART) is begun for human immunodeficiency virus type 1 (HIV-1) infection. However, it is unknown whether this dominance continues throughout the first year of treatment. To examine this question, 10 subjects who had a positive response to HAART for 1 year were selected from a cohort of 20 who were receiving this treatment. Flow cytometry, which was used to characterize CD4(+) T cell subsets by immunophenotype, demonstrated that cells programmed to traffic through lymph nodes, irrespective of their memory or naive phenotype, continued to best account for increases in CD4(+) T cells, even 1 year after starting HAART. This suggests that, although this pool is preferentially depleted during HIV-1 infection, HAART allows for reaccumulation of these cells for at least 1 year. Furthermore, it suggests that phenotypic differences based on markers of lymphocyte trafficking may be more relevant for understanding HIV-1 pathogenesis than are naive and memory markers alone. |
| Databáze: | OpenAIRE |
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