Tripolyphosphate-crosslinked chitosan/poly (ethylene oxide) electrospun nanofibrous mats as a floating gastro-retentive delivery system for ranitidine hydrochloride
| Autor: | Hamidreza Motasadizadeh, Hassan Farhadnejad, Behrouz Foroughi-Nia, Behzad Darbasizadeh |
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| Rok vydání: | 2017 |
| Předmět: |
Bioadhesive
Clinical Biochemistry Nanofibers Pharmaceutical Science 02 engineering and technology 010402 general chemistry Ranitidine 01 natural sciences Analytical Chemistry Polyethylene Glycols Chitosan chemistry.chemical_compound Drug Delivery Systems Polyphosphates Drug Discovery medicine Thermal stability Dissolution Spectroscopy Ethylene oxide Chemistry Viscosity 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences Gastrointestinal Tract Drug Liberation Chemical engineering Nanofiber Delayed-Action Preparations Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 153 |
| ISSN: | 1873-264X |
| Popis: | The present study describes the fabrication of Tripolyphosphate (TPP)-crosslinked nanofibrous mats based on chitosan for use as a floating gastro-retentive delivery system. TPP-crosslinked chitosan (CH)/poly (ethylene oxide) (PEO)- ranitidine hydrochloride (RH) electrospun nanofibers (75.27 ± 2.10 nm) were prepared by electrospinning 70% v/v acetic acid solutions, and followed by crosslinking by TPP anions. The mechanical, structural and morphological properties of the prepared nanofibers were evaluated via tensile testing, XRD, FT-IR, TGA, NMR, AFM and SEM experimental techniques. The prepared nanofibrous mats showed a pH sensitive swelling profile with maximum water absorbing at pH 1.2. Results obtained from above experimental techniques indicated that crosslinking process did not significantly altered morphological property of nanofibers but rather decreased their diameter and swelling degree, and increased their mechanical properties, thermal stability and bioadhesive strength. Viscosity measurements showed that the addition of PEO and RH to the chitosan solution, depending to its concentration lead to decrease in the viscosity of its solution. Also, floating test showed that the prepared nanofibrous mats remain floated onto surface of the dissolution medium for more than 48 h. Based on in- vitro drug release data analysis, TPP-crosslinked CH/PEO nanofibrous mats decreased initial burst release and it was exhibited a sustained release profile for the RH from the TPP-crosslinked CH/PEO-RH electrospun nanofibrous mats. |
| Databáze: | OpenAIRE |
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