Association of arsenic and kidney dysfunction in people with diabetes and validation of its effects in rats
| Autor: | Sheng Ling Wang, Jack C. Ng, Ling Zhang, Daphne Huang, Qin Lin, J. P. Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male Rural Population China medicine.medical_specialty Urinary system chemistry.chemical_element Renal function Arsenic Diabetes Complications chemistry.chemical_compound Internal medicine Diabetes mellitus Arsenic Poisoning medicine Animals Humans Triglycerides lcsh:Environmental sciences Glucuronidase General Environmental Science lcsh:GE1-350 Triglyceride business.industry urogenital system medicine.disease Rats Lipoproteins LDL Arsenic contamination of groundwater Cholesterol Endocrinology chemistry Toxicity Kidney Failure Chronic Female Lipoproteins HDL business Water Pollutants Chemical Kidney disease |
| Zdroj: | Environment International, Vol 35, Iss 3, Pp 507-511 (2009) |
| ISSN: | 0160-4120 |
| Popis: | We studied villagers with and without diabetes from arsenic-endemic areas and a nearby control site in Xinjiang Autonomous Region, PR China. Water and urinary arsenic were assayed for exposure measurement. Urinary NAG (N-acetyl-β-glucosaminidase), a kidney function test, blood glucose, triglyceride, cholesterol, high density lipid and low density lipid were measured. Villagers from endemic areas were found to have higher urinary arsenic concentrations. The NAG results also suggest that chronic arsenic exposure presents a significant adverse impact on the kidney function of villagers in the endemic areas. However, blood glucose levels of diabetes individuals were lower than those from the control site. These observations were validated in rats which were chronically exposed to arsenic in drinking water. The distinct relationship between chronic arsenic exposure and diabetes mellitus requires further investigation. A rodent model is a useful tool for study of this type. Keywords: Arsenic, Diabetes, Kidney dysfunction, NAG, N-acetyl-β-glucosaminidase, China |
| Databáze: | OpenAIRE |
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