Effects of dressing type on 3D tissue microdeformations during negative pressure wound therapy: a computational study
| Autor: | K. Kieswetter, Y. Zhao, Balakrishna Haridas, Robert Peyton Wilkes |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Materials science
medicine.medical_treatment Finite Element Analysis Polyurethanes Biomedical Engineering Wound surface Occlusive Dressings Models Biological Granulation Physiology (medical) Negative-pressure wound therapy Shear stress medicine Humans Computer Simulation Air Pressure Wound Healing Tissue Model Granulation tissue Computational Biology Pressure level Occlusive dressing medicine.anatomical_structure Granulation Tissue Microscopy Electron Scanning Wounds and Injuries Stress Mechanical Negative-Pressure Wound Therapy Biomedical engineering |
| Zdroj: | Journal of biomechanical engineering. 131(3) |
| ISSN: | 0148-0731 |
| Popis: | Vacuum-assisted closure® (VAC®) therapy, also referred to as vacuum-assisted closure® negative pressure wound therapy (VAC® NPWT), delivered to various dermal wounds is believed to influence the formation of granulation tissue via the mechanism of microdeformational signals. In recent years, numerous experimental investigations have been initiated to study the cause-effect relationships between the mechanical signals and the transduction pathways that result in improved granulation response. To accurately quantify the tissue microdeformations during therapy, a new three-dimensional finite element model has been developed and is described in this paper. This model is used to study the effect of dressing type and subatmospheric pressure level on the variations in the microdeformational strain fields in a model dermal wound bed. Three-dimensional geometric models representing typical control volumes of NPWT dressings were generated using micro-CT scanning of VAC® GranuFoam®, a reticulated open-cell polyurethane foam (ROCF), and a gauze dressing (constructed from USP Class VII gauze). Using a nonlinear hyperfoam constitutive model for the wound bed, simulated tissue microdeformations were generated using the foam and gauze dressing models at equivalent negative pressures. The model results showed that foam produces significantly greater strain than gauze in the tissue model at all pressures and in all metrics (p |
| Databáze: | OpenAIRE |
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