Trigonelline Demonstrated Ameliorative Effects in Dexamethasone Induced Osteoporotic Rats
| Autor: | Mohd Ishaq, Akshoo Rathi, Abul Kalam Najmi, Mohd Akhtar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Osteoporosis chemistry.chemical_element Phytoestrogens Calcium 01 natural sciences Dexamethasone Bone resorption 03 medical and health sciences chemistry.chemical_compound Alkaloids 0302 clinical medicine Bone Density Trigonelline Internal medicine Drug Discovery medicine Animals Humans Femur Rats Wistar Bone mineral biology 010405 organic chemistry business.industry Cartilage Acid phosphatase X-Ray Microtomography General Medicine medicine.disease Rats 0104 chemical sciences Disease Models Animal Trigonella Endocrinology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis biology.protein business medicine.drug |
| Zdroj: | Drug Research. 70:257-264 |
| ISSN: | 2194-9387 2194-9379 |
| DOI: | 10.1055/a-1147-5724 |
| Popis: | Aim Trigonelline is a potent phytochemical present in fenugreek, which has strong anti-oxidant and phytoestrogenic activities. This study was carried out to investigate this estrogenic activity as a possible mechanisms involved in preventing the symptoms of osteoporosis in dexamethasone induced osteoporosis in rats. Materials and Methods Wistar rats were randomly divided into eight groups, six animals in each group. Osteoporosis was induced using dexamethasone 0.1mg/kg subcutaneously in rats for three times per week for 8 consecutive weeks and treatment with drugs up to 12 weeks as per the treatment schedule described. After 12 weeks, rats were sacrificed; blood samples were collected from each rat and the clear, non hemolysed supernatant sera was used for biochemical examinations. Femurs were used for Bone Mineral Density (BMD), microcomputed tomography (Micro CT), histology and biochemical examinations. Results BMD, bone micro structure, serum calcium, phosphorus level and serum estradiol levels were decreased while serum PTH levels, SAP and acid phosphatase (ACP) were elevated in dexamethasone treated rats as compared to control (p Conclusion Our results confirm the estrogenic activity of triogonelline, which is responsible for its effects; still, it needs further evaluation in other animal models to provide a more conclusive view for its therapeutic usefulness in osteoporosis. |
| Databáze: | OpenAIRE |
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