Seroprevalence of measles and rubella antibodies in pregnant women Haiti, 2012
| Autor: | Jacques Boncy, David L. Fitter, Gilson Paluku, Gloria J. Rey, Renette Anselme, John Vertefeuille, Brendan Flannery, Barbara J. Marston, Rania A. Tohme, Mark Griswold |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Antibodies Viral Measles Rubella Immunoglobulin G Rubella antibodies Herd immunity Young Adult Pregnancy Seroepidemiologic Studies medicine Seroprevalence Humans Congenital rubella syndrome General Veterinary General Immunology and Microbiology biology Obstetrics business.industry Public Health Environmental and Occupational Health virus diseases medicine.disease Haiti Infectious Diseases Immunology biology.protein Molecular Medicine Female Antibody business Measles-Mumps-Rubella Vaccine |
| Zdroj: | Vaccine. 32(1) |
| ISSN: | 1873-2518 |
| Popis: | Background Haiti had set a national goal to eliminate measles and rubella, as well as congenital rubella syndrome (CRS) by 2010. A 2007–2008 nationwide measles and rubella vaccination campaign targeting 1–19 years, however, reached only 79% of the target population. To assess whether population immunity was adequate to support elimination, we conducted a national serosurvey. Methods We systematically selected 740 serum specimens collected from pregnant women in a 2012 national antenatal HIV sentinel serosurvey across four age strata: 15–19, 20–24, 25–29 and 30–39 years. Sera were tested for measles and rubella specific immunoglobulin G antibodies (IgG) using commercial immunoassays. We classified sera as seropositive, seronegative or indeterminate per manufacturer's instructions, and analyzed seroprevalence according to age strata, and rural or urban residence. We assessed immunity by estimating antibody concentrations in international units per milliliter (IU/mL) for seropositive and indeterminate sera. Measles IgG concentrations >0.12 IU/mL and rubella IgG concentrations >10 IU/mL were considered clinically protective. Results Of 740 sera, 696 (94.1%) were seropositive and 20 (2.7%) were indeterminate for measles IgG; overall 716 (96.8%) sera had IgG concentrations >0.12 IU/mL. For rubella IgG, 691 (93.4%) sera were seropositive and 1 (0.1%) was indeterminate; a total of 687 (92.8%) had IgG concentrations >10 IU/mL. Measles seropositivity varied across age strata ( p = 0.003); seropositivity increased from 88.6% among 15–19 year olds to 98.4% among 30–39 year olds (Cochran–Armitage trend test ≤ 0.0001). Rubella seropositivity did not differ across age strata. There were no statistically significant differences in measles or rubella seropositivity by urban versus rural residence. Conclusion Despite previous low vaccination coverage for measles, results from this serosurvey indicate high levels of measles and rubella seropositivity in pregnant women, and contribute to the evidence for measles, rubella and CRS elimination from Haiti by the target date. |
| Databáze: | OpenAIRE |
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