Oocyte competency is the key to embryo potential
| Autor: | Keri Kalmbach, Molly Kumar, David L. Keefe |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Genetics
Mitochondrial DNA animal structures Reproduction Cell Cycle Obstetrics and Gynecology Embryonic Development Embryo Locus (genetics) Polar Bodies Biology Oocyte Genome Cell biology Polar body medicine.anatomical_structure Reproductive Medicine Homologous chromosome medicine Oocytes Animals Humans Chromatid Female Maternal Age |
| Zdroj: | Fertility and sterility. 103(2) |
| ISSN: | 1556-5653 |
| Popis: | The oocyte is the major determinant of embryo developmental competence in women. It delivers half the chromosomal complement to the embryo, but the maternal and paternal genomes are neither symmetrical nor equal in their contributions to embryo fate. Unlike the paternal genome, the maternal genome carries a heavy footprint of parental aging. Indeed, age is the single best predictor of reproductive outcome in women, and the oocyte is the locus of reproductive aging in women. The oocyte transmits not only the mother's nuclear but also her mitochondrial genome to the embryo, and mitochondrial DNA is known to be especially susceptible to aging. Morphological studies of the oocyte and its associated cumulus corona cells provide only marginal value in the assessment of embryo developmental potential. A number of novel technologies, however, have improved the noninvasive assessment of oocyte quality. Moreover, during maturation, the oocyte ejects half its homologous chromosomes into the first polar body and half its chromatids into the second polar body. Polar body DNA is remarkably similar to that of the oocyte, so analysis of polar body DNA provides a window into the oocyte's genome and telomeres, which may enhance prediction of embryo developmental competence. |
| Databáze: | OpenAIRE |
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