Overexpression of TACC3 is correlated with tumor aggressiveness and poor prognosis in prostate cancer
Autor: | Liping Ye, Min Wang, Xinsheng Peng, Wei Guo, Shuai Huang, Qiji Li |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine China Statistics as Topic Biophysics urologic and male genital diseases Sensitivity and Specificity Biochemistry Metastasis 03 medical and health sciences Prostate cancer Downregulation and upregulation Risk Factors Biomarkers Tumor Prevalence Humans Medicine Gene silencing Neoplasm Invasiveness Molecular Biology Survival analysis Gene knockdown business.industry Wnt signaling pathway Prostatic Neoplasms Reproducibility of Results Cell Biology Middle Aged Prognosis medicine.disease Survival Rate 030104 developmental biology Tumor progression Cancer research business Microtubule-Associated Proteins |
Zdroj: | Biochemical and Biophysical Research Communications. 486:872-878 |
ISSN: | 0006-291X |
Popis: | Transforming acidic coiled-coil (TACC3), a member of the TACC family, has been shown to be deregulated in various cancers and involved in tumor progression. However, its biological role and molecular mechanism in prostate cancer (PCa) have not been elucidated. Herein, we reported that TACC3 was markedly upregulated in metastatic PCa. The upregulation of TACC3 was significantly associated with the metastasis status, tumor stage, total prostate-specific antigen (PSA) level, and Gleason score in patients with PCa. Moreover, a Kaplan-Meier survival analysis showed that patients with PCa who had high TACC3 expression experienced shorter disease-free survival than patients with a low TACC3 expression. In addition, the knockdown of TACC3 dramatically reduced the migratory speed and invasiveness of PCa cells. Furthermore, silencing TACC3 markedly suppressed the Wnt/β-catenin signaling pathway. Taken together, these findings uncover a supportive role for TACC3 in PCa metastasis, which is mediated by the activation of the Wnt/β-catenin signaling pathway, suggesting that TACC3 may serve as a prognostic marker in patients with metastatic PCa. |
Databáze: | OpenAIRE |
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