Current challenges facing the assessment of the allergenic capacity of food allergens in animal models
| Autor: | Bøgh, Katrine Lindholm, van Bilsen, Jolanda, Głogowski, Robert, López-Expósito, Iván, Bouchaud, Grégory, Blanchard, Carine, Bodinier, Marie, Smit, Joost, Pieters, Raymond, Bastiaan-Net, Shanna, de Wit, Nicole, Untersmayr, Eva, Adel-Patient, Karine, Knippels, Leon, Epstein, Michelle M, Noti, Mario, Nygaard, Unni Cecilie, Kimber, Ian, Verhoeckx, Kitty, O'Mahony, Liam, Sub IRAS Tox ITX (immunotoxicologie), Sub General Pharmacology, dIRAS RA-1, Pharmacology |
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| Přispěvatelé: | National Food Institute, Technical University of Denmark [Lyngby] (DTU), TNO, Warsaw University of Life Sciences (SGGW), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Nestlé, Institute for Risk Assessment Sciences, Utrecht University [Utrecht], Wageningen University and Research Centre (WUR), Department of Pathophysiology and Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Christian Doppler Laboratory for Immunomodulation, Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris Saclay (COmUE), Danone Research, Utrecht Institute for Pharmaceutical Sciences (UIPS), Medizinische Universität Wien = Medical University of Vienna, University of Bern, Norwegian institute for public health, University of Manchester [Manchester], Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), EU, European Cooperation in Science and Technology, Swiss National Science Foundation, European Commission, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Nestlé S.A., Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sub IRAS Tox ITX (immunotoxicologie), Sub General Pharmacology, dIRAS RA-1, Pharmacology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Emerging technologies [SDV]Life Sciences [q-bio] Immunology Population RAPID - Risk Analysis for Products in Development Novel food Review Biology 03 medical and health sciences SDG 3 - Good Health and Well-being Life Food allergy [SDV.IDA]Life Sciences [q-bio]/Food engineering medicine Immunology and Allergy Food and Nutrition [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Food allergens education VLAG Food Health & Consumer Research 2. Zero hunger education.field_of_study business.industry animal models food allergy hazard identification novel allergens medicine.disease Test protein 3. Good health Biotechnology Animal models 030104 developmental biology Health & Consumer Research Hazard identification Agriculture Food Identification (biology) ELSS - Earth Life and Social Sciences business Novel allergens Healthy Living |
| Zdroj: | Clinical and Translational Allergy Clinical and Translational Allergy, 6 Clinical and Translational Allergy, BioMed Central, 2016, 6 (1), ⟨10.1186/s13601-016-0110-2⟩ Bøgh, Katrine Lindholm; van Bilsen, Jolanda; Głogowski, Robert; López-Expósito, Iván; Bouchaud, Grégory; Blanchard, Carine; Bodinier, Marie; Smit, Joost; Pieters, Raymond; Bastiaan-Net, Shanna; de Wit, Nicole; Untersmayr, Eva; Adel-Patient, Karine; Knippels, Leon; Epstein, Michelle M; Noti, Mario; Nygaard, Unni Cecilie; Kimber, Ian; Verhoeckx, Kitty and O'Mahony, Liam (2016). Current challenges facing the assessment of the allergenic capacity of food allergens in animal models. Clinical and translational allergy, 6(21), p. 21. BioMed Central 10.1186/s13601-016-0110-2 Digital.CSIC. Repositorio Institucional del CSIC instname Clinical and Translational Allergy, 2016, 6 (1), ⟨10.1186/s13601-016-0110-2⟩ Bøgh, K L, van Bilsen, J, Głogowski, R, López-Expósito, I, Bouchaud, G, Blanchard, C, Bodinier, M, Smit, J, Pieters, R, Bastiaan-Net, S, de Wit, N, Untersmayr, E, Adel-Patient, K, Knippels, L, Epstein, M M, Noti, M, Nygaard, U C, Kimber, I, Verhoeckx, K & O'Mahony, L 2016, ' Current challenges facing the assessment of the allergenic capacity of food allergens in animal models ', Clinical and Translational Allergy, vol. 6, no. 1 . https://doi.org/10.1186/s13601-016-0110-2 Clinical and Translational Allergy 6 (2016) Clinical and Translational Allergy, 1, 6 Clinical and Translational Allergy, 6. BioMed Central Clinical and Translational Allergy 1 (6), . (2016) |
| ISSN: | 2045-7022 0030-1442 |
| DOI: | 10.1186/s13601-016-0110-2⟩ |
| Popis: | Bøgh et al. Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of new protein sources into the diet, such as newly developed innovative foods or foods produced using new technologies and production processes, insects, algae, duckweed, or agricultural products from third countries, creates the opportunity for development of new food allergies, and this in turn has driven the need to develop test methods capable of characterizing the allergenic potential of novel food proteins. There is no doubt that robust and reliable animal models for the identification and characterization of food allergens would be valuable tools for safety assessment. However, although various animal models have been proposed for this purpose, to date, none have been formally validated as predictive and none are currently suitable to test the allergenic potential of new foods. Here, the design of various animal models are reviewed, including among others considerations of species and strain, diet, route of administration, dose and formulation of the test protein, relevant controls and endpoints measured. The authors are all part of the COST Action FA1402 entitled: Improving Allergy Risk Assessment Strategy for New Food Proteins (ImpARAS). LOM is supported by Swiss National Foundation grants (Project Numbers: CRSII3_154488 and 310030-144219) and European Union research grants. |
| Databáze: | OpenAIRE |
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