A Randomized Control Trial of Oral Sucrose Solution for Prevention of Hypoglycemia in High Risk Infants
| Autor: | Nithipun Suksumek, Pithi Chanvorachote, Sarivirin Surachaidungtavil |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male Sucrose Cancer Research medicine.medical_specialty Time Factors Brain damage Hypoglycemia Enteral administration Gastroenterology General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sucrose solution Randomized controlled trial Pregnancy Risk Factors law Internal medicine medicine Birth Weight Humans Adverse effect Pharmacology business.industry Neonatal hypoglycemia Infant Newborn Infant medicine.disease Solutions chemistry 030220 oncology & carcinogenesis Female medicine.symptom business Research Article |
| Zdroj: | In Vivo |
| ISSN: | 1791-7549 0258-851X |
| Popis: | Background: Neonatal hypoglycemia is found in up to 15% of neonates and 50% of those with risk factors. Hypoglycemia can cause brain damage and increase risk of developmental delay. Nevertheless, the data regarding hypoglycemia prevention by oral sucrose are still limited. The present study aimed to investigate whether oral sucrose solution can prevent hypoglycemia in high-risk infants. Patients and Methods: Four hundred and twenty-five infants with high hypoglycemic risk were randomized into two groups (214 infants in the intervention and 211 infants in the control groups). The intervention group received one dose of 0.8 ml/kg of 24% oral sucrose solution followed by enteral feed and was compared to the control group receiving enteral feed alone. Glucose levels were evaluated by Dextrostrix. Results: There was no significant difference in antenatal and perinatal risk factors of neonatal hypoglycemia between groups. Glucose level on admission was 72.1±20.3 and 72.1±24.1 mg/dl in the intervention and control groups, respectively. Although no significant difference was recognized in terms of capillary blood glucose levels between groups, data analysis revealed that the glucose increase over time was significantly higher in the intervention group at 1 h (mean±SE=3.61±1.27 mg/dl; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|