Effect of hypertension on the resting-state functional connectivity in patients with Alzheimer's disease (AD)
| Autor: | Jin Young Park, Eun Lee, Byoung Hoon Oh, Jeonghun Ku, Eosu Kim, Chang Hyung Hong, Jinna Kim, Kee Namkoong, Sang Joon Son |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Aging medicine.medical_specialty Health (social science) Disease computer.software_genre Gyrus Cinguli Functional Laterality Atrophy Alzheimer Disease Voxel Internal medicine medicine Humans Aged Cerebral Cortex Brain Mapping medicine.diagnostic_test Resting state fMRI Functional connectivity Brain Middle Aged medicine.disease Magnetic Resonance Imaging Pathophysiology Posterior cingulate Hypertension Cardiology Female Geriatrics and Gerontology Psychology Functional magnetic resonance imaging Gerontology Neuroscience computer |
| Zdroj: | Archives of Gerontology and Geriatrics. 60:210-216 |
| ISSN: | 0167-4943 |
| Popis: | Background/Objectives Although hypertension is known to be a risk factor for AD, the effects of hypertension on brain function in AD patients are not well understood. We investigated alterations in resting-state functional connectivity according to the presence of hypertension in AD patients by using a method of correlation analysis based on a seed region in the posterior cingulate cortex (PCC). We also determined whether differences in resting-state connectivity were associated with gray matter atrophy. Methods Thirty-seven AD patients (18 patients with hypertension and 19 patients without hypertension) underwent the resting-state functional magnetic resonance imaging. We obtained the PCC maps by a temporal correlation method, to identify alterations in the functional connectivity of the PCC in hypertensive group relative to non-hypertensive group. Voxel-based morphometry analysis was also applied to adjust the confounding effect of gray matter atrophy. Results We detected a decreased connectivity to the PCC in the regions of subgenual anterior cingulated cortex (ACC) in hypertensive group relative to non-hypertensive group. However, we observed a pattern of increased connectivity between the PCC and the left inferior parietal cortex in hypertensive group. After correction for gray matter atrophy, all detected regions still remained significant. Conclusions Altered connectivity in AD patients with hypertension suggests the possibility that hypertension impairs resting-state functional connectivity of the AD brain, inducing a compensational process outside the impaired networks or disequilibrium in brain connectivity. This finding may account for an additional contribution of hypertension to the pathophysiology of AD. |
| Databáze: | OpenAIRE |
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