Ilb® attenuates clinical symptoms and serum biomarkers of oxidative/nitrosative stress and mitochondrial dysfunction in patients with amyotrophic lateral sclerosis
| Autor: | Bernardo M. Ropero, Giacomo Lazzarino, Valentina Di Pietro, Angela Maria Amorini, Benedetta Manca, Antonio Belli, Lars Bruce, Zsuzsanna Nagy, Barbara Tavazzi, Ann Logan, Nicholas M. Barnes, Miriam Wissam Saab, Giuseppe Lazzarino, Lennart I. Persson, Renata Mangione |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Bioenergetics
Low molecular weight-dextran sulphate Medicine (miscellaneous) Disease Oxidative phosphorylation Pharmacology Article Antioxidants Low molecular weight dextran N-acetylaspartate Serum biomarkers Medicine In patient Amyotrophic lateral sclerosis business.industry Energy metabolism medicine.disease Treatment period Amino acids Oxidative/nitrosative stress HPLC business Mitochondrial dysfunction |
| Zdroj: | Journal of Personalized Medicine Journal of Personalized Medicine, Vol 11, Iss 794, p 794 (2021) Volume 11 Issue 8 |
| Popis: | Oxidative/nitrosative stress and mitochondrial dysfunction is a hallmark of amyotrophic lateral sclerosis (ALS), an invariably fatal progressive neurodegenerative disease. Here, as an exploratory arm of a phase II clinical trial (EudraCT Number 2017-005065-47), we used high performance liquid chromatography(HPLC) to investigate changes in the metabolic profiles of serum from ALS patients treated weekly for 4 weeks with a repeated sub-cutaneous dose of 1 mg/kg of a proprietary low molecular weight dextran sulphate, called ILB®. A significant normalization of the serum levels of several key metabolites was observed over the treatment period, including N-acetylaspartate (NAA), oxypurines, biomarkers of oxidative/nitrosative stress and antioxidants. An improved serum metabolic profile was accompanied by significant amelioration of the patients’ clinical conditions, indicating a response to ILB® treatment that appears to be mediated by improvement of tissue bioenergetics, decrease of oxidative/nitrosative stress and attenuation of (neuro)inflammatory processes. |
| Databáze: | OpenAIRE |
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