Nutrition in wound healing: investigation of the molecular mechanisms, a narrative review
Autor: | Carmen Laurino, Beniamino Palmieri, Maria Vadalà |
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Rok vydání: | 2019 |
Předmět: |
Vitamin
Nursing (miscellaneous) medicine.medical_treatment Nutritional Status Pharmacology Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hyaluronic acid medicine Humans 030212 general & internal medicine 030304 developmental biology Epithelial cell differentiation chemistry.chemical_classification Pressure Ulcer 0303 health sciences Wound Healing business.industry Granulation tissue Amino acid medicine.anatomical_structure Cytokine chemistry Dietary Supplements Fundamentals and skills Wound healing business |
Zdroj: | Journal of wound care. 28(10) |
ISSN: | 0969-0700 |
Popis: | Nutrition can be outlined in terms of epigenetic signals influencing each of the wound healing steps (haemostasis, inflammatory, proliferative and remodelling phase). Specific nutrients, such as amino acids, minerals, vitamins, natural compounds and herbal extracts, target DNA-regulating transcription factors, cytokines, extracellular matrix proteins and glycosaminoglycan, and are specifically involved in the wound healing process. This review focuses on experimental in vivo and clinical evidence of dietary supplements administration in pressure ulcers. A good nutritional status is, for example, fundamental to the haemostasis phase of skin wounds. In the inflammatory phase, vitamin A enhances cytokine release, bromelain and amino acids prevent prolonged inflammatory events, while vitamin C enhances neutrophil migration and lymphocyte activation. In the proliferative phase, vitamin C and Centella asiatica are required for collagen synthesis. Glucosamine enhances hyaluronic acid production, vitamin A promotes epithelial cell differentiation, zinc is required for DNA and protein synthesis and cell division, and Aloe vera supports granulation tissue generation. Finally, in the remodelling phase, amino acids and proteins play a key role in wound scar stabilisation. |
Databáze: | OpenAIRE |
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