The role of epigenetics in the development of childhood asthma
| Autor: | Cancan Qi, Gerard H. Koppelman, Cheng-Jian Xu |
|---|---|
| Přispěvatelé: | Groningen Research Institute for Asthma and COPD (GRIAC) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Immunology
Disease Epigenesis Genetic Histones Immunology and Allergy Medicine Humans Epigenetics Child Asthma Genetics Regulation of gene expression biology business.industry Methylation Environmental Exposure DNA Methylation medicine.disease respiratory tract diseases Biomarker MicroRNAs Histone DNA methylation biology.protein business Protein Processing Post-Translational Biomarkers |
| Zdroj: | Expert review of clinical immunology, 15(12), 1287-1302. TAYLOR & FRANCIS LTD |
| ISSN: | 1744-666X |
| Popis: | Introduction: The development of childhood asthma is caused by a combination of genetic factors and environmental exposures. Epigenetics describes mechanisms of (heritable) regulation of gene expression that occur without changes in DNA sequence. Epigenetics is strongly related to aging, is cell-type specific, and includes DNA methylation, noncoding RNAs, and histone modifications.Areas covered: This review summarizes recent epigenetic studies of childhood asthma in humans, which mostly involve studies of DNA methylation published in the recent five years. Environmental exposures, in particular cigarette smoking, have significant impact on epigenetic changes, but few of these epigenetic signals are also associated with asthma. Several asthma-associated genetic variants relate to DNA methylation. Epigenetic signals can be better understood by studying their correlation with gene expression, which revealed higher presence and activation of blood eosinophils in asthma. Strong associations of nasal methylation signatures and atopic asthma were identified, which were replicable across different populations.Expert commentary: Epigenetic markers have been strongly associated with asthma, and might serve as biomarker of asthma. The causal and longitudinal relationships between epigenetics and disease, and between environmental exposures and epigenetic changes need to be further investigated. Efforts should be made to understand cell-type-specific epigenetic mechanisms in asthma. |
| Databáze: | OpenAIRE |
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